对L-谷氨酸50-L-酪氨酸50（GT）特异的免疫抑制因子。III. 由源自GT致敏淋巴细胞的抑制性提取物产生抑制性T细胞。
Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyrosine50 (GT). III. Generation of suppressor T cells by a suppressive extract derived from GT-primed lymphoid cells.
作者信息
Waltenbaugh C, Thèze J, Kapp J A, Benacerraf B
出版信息
J Exp Med. 1977 Oct 1;146(4):970-85. doi: 10.1084/jem.146.4.970.
Abstract
Injection of mice with L-glutamic acid50-L-tyrosine50 (GT)- or L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT)-specific suppressor T-cell factor (GT-TsF or GAT-TsF) up to 5 wk before antigenic challenge challenge suppresses GT-methylated bovine serum albumin (MBSA) and GAT-MBSA plaque-forming cells responses. T suppressor cells are responsible for the suppression induced by the suppressive extract as demonstrated by adoptive transfer and sensitivity to anti-Thy-1 and complement treatment. We conclude that suppressive extract induces specific suppressor T cells. The material responsible for generation of suppressor T cells is a product of the I subregion of the H-2 complex. We have excluded that suppressive quantities of antigens are present in the extract. A/J mice, which can neither be suppressed by GT nor make GT-TsF can be suppressed by BALB/c GT-tsf. Spleen cells from BALB/c GT TsF-primed A/J mice can adoptively transfer suppression to normal syngeneic recipients. A/J mice appear to be genetically defective in cells involved in factor production. These results are discussed in the light of a two-step model for induction of antigen-specific suppressor cells.
摘要
在抗原攻击前长达5周给小鼠注射L-谷氨酸50-L-酪氨酸50（GT）或L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）特异性抑制性T细胞因子（GT-TsF或GAT-TsF），可抑制GT甲基化牛血清白蛋白（MBSA）和GAT-MBSA蚀斑形成细胞反应。如通过过继转移以及对抗Thy-1和补体处理的敏感性所证明，T抑制细胞负责抑制性提取物诱导的抑制作用。我们得出结论，抑制性提取物诱导特异性抑制性T细胞。负责产生抑制性T细胞的物质是H-2复合体I亚区的产物。我们已排除提取物中存在抑制量的抗原。既不能被GT抑制也不能产生GT-TsF的A/J小鼠可被BALB/c GT-tsf抑制。来自用BALB/c GT TsF致敏的A/J小鼠的脾细胞可将抑制作用过继转移给正常同基因受体。A/J小鼠似乎在参与因子产生的细胞中存在基因缺陷。根据抗原特异性抑制细胞诱导的两步模型对这些结果进行了讨论。
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