Parent A, Sato F, Wu Y, Gauthier J, Lévesque M, Parent M
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada.
Trends Neurosci. 2000 Oct;23(10 Suppl):S20-7. doi: 10.1016/s1471-1931(00)00022-7.
Recent neuroanatomical data obtained with single-axon or single-cell labeling procedures in both rodents and primates have revealed the presence of various types of projection neurons with profusely collateralized axons within each of the major components of the basal ganglia. Such findings call for a reappraisal of current concepts of the anatomical and functional organization of the basal ganglia,which play such a crucial role in the control of motor behavior. The basal ganglia now stand as a widely distributed neuronal network, whose elements are endowed with a highly patterned set of axon collaterals. The elucidation of this finely tuned network is needed to understand the complex spatiotemporal sequence of neural events that ensures the flow of cortical information through the basal ganglia.
最近，通过单轴突或单细胞标记程序在啮齿动物和灵长类动物中获得的神经解剖学数据显示，在基底神经节的每个主要组成部分内都存在各种类型的具有大量侧支轴突的投射神经元。这些发现要求重新评估当前关于基底神经节解剖和功能组织的概念，基底神经节在运动行为控制中起着至关重要的作用。基底神经节现在是一个广泛分布的神经元网络，其组成部分具有高度模式化的轴突侧支。需要阐明这个精细调节的网络，以理解确保皮质信息通过基底神经节流动的复杂神经事件的时空序列。
