Montgomery Erwin B
Department of Neurology, National Primate Research Center, University of Wisconsin-Madison, USA.
Parkinsonism Relat Disord. 2007 Dec;13(8):455-65. doi: 10.1016/j.parkreldis.2007.07.020. Epub 2007 Oct 31.
Current theories of basal ganglia (BG) function based on suppression of activity in the ventrolateral thalamic-cortical circuits by the globus pallidus internal segment are inconsistent with accumulating evidence, demonstrating the need for reconsideration. Changes in busting, oscillatory and synchronous neuronal activities have been indicted as pathophyisological mechanisms but they are unaccompanied by any mechanistic explanatory theory and rely on the same basic assumptions as previous theories now suspect. These notions and theories are reviewed and an alternative is proposed. The systems oscillators theory presented here proposes that the BG is a network of sets of interconnected closed neural loops functioning as oscillators. Its unique physiological and pathophysiological mechanisms are explored.
目前基于苍白球内侧段对腹外侧丘脑 - 皮质回路活动抑制的基底神经节（BG）功能理论与越来越多的证据不一致，这表明有必要重新考虑。爆发性、振荡性和同步性神经元活动的变化已被认为是病理生理机制，但它们没有任何机制性的解释理论，并且依赖于与现在受到质疑的先前理论相同的基本假设。本文对这些概念和理论进行了综述，并提出了一种替代方案。这里提出的系统振荡器理论认为，基底神经节是由相互连接的闭合神经回路组成的网络，这些回路起着振荡器的作用。文中探讨了其独特的生理和病理生理机制。
