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1
The immunological consequences of antigen overload in experimental mycobacterial infections of mice.小鼠实验性分枝杆菌感染中抗原过载的免疫后果。
Clin Exp Immunol. 1975 Jan;19(1):167-77.
2
The potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products.在被分枝杆菌产物“过载”的小鼠淋巴结中，巨噬细胞对淋巴细胞的体外增强、促有丝分裂和抑制作用。
Clin Exp Immunol. 1975 Jul;21(1):163-72.
3
Strain differences in mouse cellular responses to Mycobacterium lepraemurium and BCG subcutaneous infections. I. Analysis of cell surface phenotype in local granulomas.小鼠对鼠麻风杆菌和卡介苗皮下感染的细胞反应中的品系差异。I. 局部肉芽肿中细胞表面表型分析。
Clin Exp Immunol. 1990 Jun;80(3):332-8.
4
Correlation of PPD and BCG-induced leukocyte migration inhibition, delayed cutaneous hypersensitivity, lymphocyte transformation in vitro and humoral antibodies to PPD in man.结核菌素纯蛋白衍生物（PPD）与卡介苗诱导的白细胞迁移抑制、迟发型皮肤超敏反应、体外淋巴细胞转化以及人体中针对PPD的体液抗体之间的相关性。
Eur J Immunol. 1976 Mar;6(3):163-7. doi: 10.1002/eji.1830060305.
5
Migration-inhibition response of peripheral leukocytes to tuberculin in cats sensitized with viable Mycobacterium bovis (BCG).用活卡介苗（牛型结核分枝杆菌）致敏的猫外周血白细胞对结核菌素的迁移抑制反应。
Am J Vet Res. 1977 Jun;38(6):819-22.
6
Preliminary evidence for the trapping of antigen-specific lymphocytes in the lymphoid tissue of 'anergic' tuberculosis patients.“无反应性”肺结核患者淋巴组织中抗原特异性淋巴细胞滞留的初步证据。
Clin Exp Immunol. 1976 Oct;26(1):129-32.
7
A possible relationship between delayed hypersensitivity and cell-mediated immunity.迟发型超敏反应与细胞介导免疫之间的可能关系。
Am Rev Respir Dis. 1975 Apr;111(4):373-7. doi: 10.1164/arrd.1975.111.4.373.
8
Response of the popliteal lymph node to reinfection of the hind foot pad of the mouse with Mycobacterium marinum.小鼠后足垫再次感染海分枝杆菌时腘淋巴结的反应。
J Clin Lab Immunol. 1984 Jul;14(3):155-60.
9
Immune response to Mycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I- and II-deficient knock-out mice: contribution of CD4 and CD8 T cells to acquired resistance.主要组织相容性复合体I类和II类缺陷型基因敲除小鼠对卡介苗感染的免疫反应：CD4和CD8 T细胞对获得性抗性的作用
Eur J Immunol. 1995 Feb;25(2):377-84. doi: 10.1002/eji.1830250211.
10
In vivo and in vitro responses of cats sensitized with viable Mycobacterium bovis (BCG).用活的牛分枝杆菌（卡介苗）致敏的猫的体内和体外反应。
Am J Vet Res. 1979 Nov;40(11):1613-9.

引用本文的文献

1
Pathogenesis and host response in subcutaneous alveolar hydatidosis. II. Intense plasmacellular infiltration in the paracortex of draining lymph nodes.皮下肺泡状棘球蚴病的发病机制与宿主反应。II.引流淋巴结副皮质区的强烈浆细胞浸润。
Z Parasitenkd. 1980;62(3):255-65. doi: 10.1007/BF00926566.
2
A lack of correlation between antigen-specific cellular reactions and resistance to Mycobacterium lepraemurium infection in mice.小鼠体内抗原特异性细胞反应与抗鼠麻风杆菌感染抵抗力之间缺乏相关性。
Immunology. 1981 Jun;43(2):293-301.
3
The specificity of suppressor T cells induced by chronic Mycobacterium avium infection in mice.小鼠慢性鸟分枝杆菌感染诱导的抑制性T细胞的特异性。
Clin Exp Immunol. 1981 Jan;43(1):10-9.
4
Effect of chemotherapy on suppressor T cells in BCG-infected mice.化疗对卡介苗感染小鼠中抑制性T细胞的影响。
Immunology. 1980 Aug;40(4):529-37.
5
T cell proliferation in Mycobacterium lepraemurium infection. II. Characterization of cells that transfer resistance in subcutaneously infected mice.鼠麻风杆菌感染中的T细胞增殖。II. 皮下感染小鼠中传递抗性的细胞的特征
Immunology. 1984 Apr;51(4):703-10.
6
Cutaneous unresponsiveness to Mycobacterium bovis BCG in intravenously infected mice.静脉感染小鼠中对卡介苗的皮肤无反应性
Infect Immun. 1983 Aug;41(2):453-61. doi: 10.1128/iai.41.2.453-461.1983.
7
Kinetics of immunosuppression of sporozoite-induced immunity by Mycobacterium bovis BCG.牛分枝杆菌卡介苗对子孢子诱导免疫的免疫抑制动力学
Infect Immun. 1982 Sep;37(3):1021-7. doi: 10.1128/iai.37.3.1021-1027.1982.
8
Evolution of inflammatory response and cellular immune responses in a murine model of disseminated blastomycosis.播散性芽生菌病小鼠模型中炎症反应和细胞免疫反应的演变
Infect Immun. 1985 Oct;50(1):183-9. doi: 10.1128/iai.50.1.183-189.1985.
9
Lymphocyte and lymphocyte subset numbers in blood and in bronchoalveolar lavage and pleural fluid in various forms of human pulmonary tuberculosis at presentation and during recovery.不同形式的人类肺结核患者初诊时及恢复过程中血液、支气管肺泡灌洗液和胸腔积液中的淋巴细胞及淋巴细胞亚群数量。
Thorax. 1992 Jul;47(7):513-8. doi: 10.1136/thx.47.7.513.
10
The potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products.在被分枝杆菌产物“过载”的小鼠淋巴结中，巨噬细胞对淋巴细胞的体外增强、促有丝分裂和抑制作用。
Clin Exp Immunol. 1975 Jul;21(1):163-72.

本文引用的文献

1
The compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs.脱敏豚鼠中抗原反应性淋巴细胞的区室化
J Exp Med. 1971 Sep 1;134(3 Pt 1):741-50. doi: 10.1084/jem.134.3.741.
2
The immediate effect of antigens on the cell output of a lymph node.抗原对淋巴结细胞输出量的即时影响。
Br J Exp Pathol. 1965 Aug;46(4):450-4.
3
The effect of localized injection of adjuvant material on the draining lymph node. II. Circulating lymphocytes.佐剂材料局部注射对引流淋巴结的影响。II. 循环淋巴细胞
Immunology. 1970 May;18(5):663-70.
4
A study of some fast-growing scotochromogenic mycobacteria including species descriptions of Mycobacterium gilvum (new species) and Mycobacterium duv alii (new species).对一些快速生长的暗产色分枝杆菌的研究，包括吉尔武分枝杆菌（新种）和杜瓦利分枝杆菌（新种）的种描述。
Br J Exp Pathol. 1971 Dec;52(6):627-37.
5
The relationship of delayed hypersensitivity to acquired antituberculous immunity. I. Tuberculin sensitivity and resistance to reinfection in BCG-vaccinated mice.迟发型超敏反应与获得性抗结核免疫的关系。I. 卡介苗接种小鼠的结核菌素敏感性及对再感染的抵抗力
Cell Immunol. 1970 Sep;1(3):253-65. doi: 10.1016/0008-8749(70)90047-x.
6
The distribution of 51Cr-labeled lymphocytes into antigen-stimulated mice. Lymphocyte trapping.51铬标记淋巴细胞在抗原刺激小鼠体内的分布。淋巴细胞滞留。
J Exp Med. 1971 Jul 1;134(1):224-41. doi: 10.1084/jem.134.1.224.
7
Immune responses in mice with murine leprosy.患有鼠麻风病的小鼠的免疫反应。
Clin Exp Immunol. 1970 Jan;6(1):117-24.
8
Contact sensitivity in the mouse. XII. The use of DNA synthesis in vivo to determine the anatomical location of immunological unresponsiveness to picryl chloride.小鼠中的接触性敏感。十二、利用体内DNA合成来确定对苦味酰氯免疫无反应性的解剖学位置。
Immunology. 1973 Sep;25(3):495-508.
9
The spontaneous induction of anamnestic antibody synthesis in lymph node cell cultures many months after primary immunization.初次免疫许多个月后，淋巴结细胞培养物中记忆性抗体合成的自发诱导。
J Immunol. 1973 Aug;111(2):416-23.
10
Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy.在麻风病的整个临床和组织病理学范围内，对麻风分枝杆菌及其他分枝杆菌抗原的免疫反应性。
Clin Exp Immunol. 1973 Aug;14(4):541-53.

小鼠实验性分枝杆菌感染中抗原过载的免疫后果。

The immunological consequences of antigen overload in experimental mycobacterial infections of mice.

作者信息

Rook G A

出版信息

Clin Exp Immunol. 1975 Jan;19(1):167-77.

PMID:1106912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538039/
Abstract

Mice infected in the tail with M. ulcerans developed transient cell-mediated immunity which disappeared as the bacterial load increased. Lymph node cells from animals in this late phase of the disease transformed spontaneously in vitro. This transformation was inhibited by mycobacterial antigen. Lymph node cells from mice injected intravenously with 10(8) or 10(9) BCG also transformed spontaneously in vitro. Such animals did not become foot pad test-positive. Evidence is presented that the spontaneous transformation may represent an accumulation of specifically sensitized cells due to trapping in nodes overloaded with persistent antigen. The relevance of such a phenomenon to 'desensitization' in human and animal disease is discussed.

摘要

用溃疡分枝杆菌感染尾部的小鼠产生了短暂的细胞介导免疫，随着细菌载量增加这种免疫消失。处于疾病晚期的动物的淋巴结细胞在体外自发转化。这种转化受到分枝杆菌抗原的抑制。静脉注射10⁸或10⁹个卡介苗的小鼠的淋巴结细胞在体外也自发转化。这些动物的足垫试验未呈阳性。有证据表明，这种自发转化可能代表由于在充满持续存在抗原的淋巴结中滞留而导致的特异性致敏细胞的积累。讨论了这种现象与人类和动物疾病中“脱敏”的相关性。