Meinert H, Roy T
Fluoron GmbH, Neu-Ulm, Germany.
Eur J Ophthalmol. 2000 Jul-Sep;10(3):189-97.
Semifluorinated alkanes, R(F)R(H), have a perfluorocarbon and a hydrocarbon segment in the molecule. R(F)R(H) are physically, chemically and physiologically inert, colorless, laser stable liquids with substantially reduced densities--between 1.1 and 1.7 g/cm3--and very low surface and interface tensions. R(F)R(H) are useful for unfolding a retina or for permanent tamponade. They are soluble in perfluorocarbon liquids (PFCL), hydrocarbons and silicone oils. For the first time residues of silicone oil can be extracted from the eye because R(F)R(H) are solubilizers for PFCLs and silicone oils, so they can be used as solvents or solubilizers for drugs and medicaments. Therefore R(F)R(H) are excellent candidates for use in the ophthalmic field.
半氟化烷烃，R(F)R(H)，分子中含有全氟化碳和烃链段。R(F)R(H)具有物理、化学和生理惰性，是无色、激光稳定的液体，密度显著降低，在1.1至1.7 g/cm³之间，表面张力和界面张力极低。R(F)R(H)可用于展开视网膜或进行永久性填塞。它们可溶于全氟化碳液体（PFCL）、烃类和硅油。由于R(F)R(H)是PFCL和硅油的增溶剂，首次可以从眼中提取硅油残留，因此它们可用作药物和药剂的溶剂或增溶剂。所以R(F)R(H)是眼科领域的极佳候选材料。
