Medina S, Del Río M, Hernanz A, De la Fuente M
Departamento de Biología Animal II (Fisiología Animal), Facultad de Ciencias Biológicas, Universidad Complutense, Madrid, Spain.
Peptides. 2000 Sep;21(9):1403-9. doi: 10.1016/s0196-9781(00)00284-9.
Neuropeptide Y (NPY) modulates several aspects of the immune response but it is not known whether NPY responsiveness is altered with aging. In this work, the in vitro effect of NPY at concentrations ranging from 10(-)(14) M to 10(-)(7) M on lymphoproliferation has been studied in spleen, axillary node and thymus leukocytes from young, adult, mature and old BALB/c mice. The spontaneous proliferation of spleen lymphocytes from young mice was significantly stimulated by NPY. In response to the mitogen Con A, lymphoproliferation and IL-2 release by lymphocytes were inhibited significantly by NPY, these effects disappearing with aging. The results show that NPY is a modulator of lymphoproliferation and that this effect disappears progressively with age. Moreover, this regulatory role of NPY may be carried out through a decrease in IL-2 production.
神经肽Y（NPY）可调节免疫反应的多个方面，但尚不清楚NPY的反应性是否会随着衰老而改变。在这项研究中，研究了浓度范围为10^(-14) M至10^(-7) M的NPY对年轻、成年、成熟和老年BALB/c小鼠脾脏、腋窝淋巴结和胸腺白细胞中淋巴细胞增殖的体外作用。NPY显著刺激了年轻小鼠脾脏淋巴细胞的自发增殖。在对有丝分裂原Con A的反应中，NPY显著抑制了淋巴细胞的增殖和IL-2释放，这些作用随着衰老而消失。结果表明，NPY是淋巴细胞增殖的调节剂，且这种作用会随着年龄的增长而逐渐消失。此外，NPY的这种调节作用可能是通过减少IL-2的产生来实现的。
