Marigo F A, Finger P T, McCormick S A, Iezzi R, Esaki K, Ishikawa H, Liebmann J M, Ritch R
Department of Opthalmology, The New York Eye and Ear Infirmary, 310 E 14th St, New York, NY 10003, USA.
Arch Ophthalmol. 2000 Nov;118(11):1515-21. doi: 10.1001/archopht.118.11.1515.
To correlate ultrasound biomicroscopic images of iris and ciliary body melanomas with their histopathologic features.
Ultrasound biomicroscopy was performed in 3 cases of iris melanoma and in 3 cases of ciliary body melanoma. Cross-sectional ultrasound biomicroscopic images were compared with findings from clinical examination and light microscopy to evaluate associations between their histopathologic, surface, and internal ultrasound characteristics. Unique images of intrastomal and obscured posterior tumor margins were visualized by ultrasound biomicroscopy.
Results of this study revealed that ultrasound biomicroscopy offers an accurate method to evaluate tumor shape, reflectivity, and local invasion. Neoplastic tissue had only medium echogenicity. Enlarged vessels were correlated to echolucent spaces in the iris stroma. Anterior tumor margins were found within the iris stroma, within the anterior chamber angle, and on the endothelial surface of the cornea. Posterior tumor extension was noted to encroach onto the lens, into the sclera, and serous peripheral retinal detachments were associated with ciliary body tumors.
Ultrasound biomicroscopic images correlated well with histopathologic features of anterior uveal melanomas including shape, reflectivity, and local extension. Arch Ophthalmol. 2000;118:1515-1521
将虹膜和睫状体黑色素瘤的超声生物显微镜图像与其组织病理学特征相关联。
对3例虹膜黑色素瘤和3例睫状体黑色素瘤进行超声生物显微镜检查。将横断面超声生物显微镜图像与临床检查及光学显微镜检查结果进行比较，以评估其组织病理学、表面及内部超声特征之间的关联。通过超声生物显微镜观察到瘤内及模糊的肿瘤后缘的独特图像。
本研究结果显示，超声生物显微镜提供了一种评估肿瘤形状、反射率及局部浸润的准确方法。肿瘤组织仅具有中等回声性。扩张的血管与虹膜基质中的无回声间隙相关。肿瘤前缘位于虹膜基质内、前房角内及角膜内皮表面。观察到肿瘤向后延伸侵犯晶状体、巩膜，浆液性周边视网膜脱离与睫状体肿瘤相关。
超声生物显微镜图像与前部葡萄膜黑色素瘤的组织病理学特征（包括形状、反射率及局部延伸）相关性良好。《眼科学文献》。2000年；118：1515 - 1521
