Bani S, Kaul A, Jaggi B S, Suri K A, Suri O P, Sharma O P
Department of Pharmacology, Regional Research Laboratory, Canal Road, Jammu, India.
Fitoterapia. 2000 Dec;71(6):655-62. doi: 10.1016/s0367-326x(00)00225-2.
The hydrosoluble fraction of Euphorbia royleana latex (AER), administered by gavage at doses of 50-200 mg/kg, showed dose-dependent anti-inflammatory and anti-arthritic effects in different acute and chronic test models in rats and mice. It reduced the exudate volume and the migration of leukocytes and showed a poor inhibitory effect on the granuloma formation induced by cotton pellets, while it had a low ulcerogenic score. The oral LD(50) was more than 1500 mg/kg in both rats and mice.
大戟乳胶的水溶性部分（AER），以50-200毫克/千克的剂量经口灌胃给药，在大鼠和小鼠的不同急性和慢性试验模型中显示出剂量依赖性的抗炎和抗关节炎作用。它减少了渗出液体积和白细胞迁移，对棉球诱导的肉芽肿形成显示出较弱的抑制作用，同时其致溃疡评分较低。大鼠和小鼠的口服半数致死量均超过1500毫克/千克。
