Mastellone I, Polichetti E, Grès S, Domingo N, Marin V, Lorec A M, Farnarier C, Portugal H, Kaplanski G, Chanussot F
INSERM U. 476, Hôpital Sainte Marguerite, Marseille, France.
J Nutr Biochem. 2000 Sep;11(9):461-6. doi: 10.1016/s0955-2863(00)00115-7.
The beneficial metabolic effects of dietary soybean lecithin on lipid metabolism are now more clearly established. The intestinal absorption of cholesterol is decreased by soybean phosphatidylcholine-enriched diet and results in a cholesterol-lowering effect. There is an enhancement of the cholesterol efflux by endothelial cells incubated with soybean phosphatidylcholines, and a stimulation of the reverse cholesterol transport by high density lipoprotein-phosphatidylcholines. As a result of all these processes, phosphatidylcholines provided by the soybean lecithin metabolism appear to be key molecules controlling the biodynamic exchanges of lipids. They regulate homeostasis of cholesterol and fatty acids by decreasing their synthesis and promoting cholesterol oxidation into bile salts. Finally, the outcome is the increase in bile secretion of these lipids and/or their metabolite forms. Such findings constitute promising goals in the field of nutritional effects of soybean lecithin in the treatment or prevention of hyperlipidemia and related atherosclerosis.
膳食大豆卵磷脂对脂质代谢的有益代谢作用现已得到更明确的确立。富含大豆磷脂酰胆碱的饮食可降低肠道对胆固醇的吸收，并产生降胆固醇作用。用大豆磷脂酰胆碱孵育的内皮细胞可增强胆固醇流出，高密度脂蛋白 - 磷脂酰胆碱可刺激胆固醇逆向转运。由于所有这些过程，大豆卵磷脂代谢产生的磷脂酰胆碱似乎是控制脂质生物动力学交换的关键分子。它们通过减少胆固醇和脂肪酸的合成并促进胆固醇氧化为胆汁盐来调节胆固醇和脂肪酸的稳态。最后，结果是这些脂质和/或其代谢物形式的胆汁分泌增加。这些发现为大豆卵磷脂在治疗或预防高脂血症及相关动脉粥样硬化的营养作用领域构成了有前景的目标。
