Rao S K, Ranjan Sen P, Fogla R, Gangadharan S, Padmanabhan P, Badrinath S S
Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India.
Cornea. 2000 Nov;19(6):820-3. doi: 10.1097/00003226-200011000-00012.
To describe corneal endothelial cell density and morphology in the Indian population and to compare endothelial cell characteristics in the Indian population with data available in literature for American and Japanese populations.
Specular microscopy and corneal pachymetry were performed in both eyes of 537 normal Indian volunteers, aged 20-87 years. Parameters studied included endothelial cell density, cell area, coefficient of variation (CV) in cell area and hexagonality.
Mean endothelial cell density in the study population was 2,525 +/- 337 cells/mm2. There was a statistically significant decrease in endothelial cell density with age (p < 0.001, correlation -0.387) and the rate of cell loss was 0.3% per year. There was also a statistically significant increase in mean cell area (p < 0.001, correlation 0.362) and CV (p = 0.02, correlation 0.096), and decrease in percentage of hexagonal cells (p = 0.01, correlation -0.127) with increasing age. There was no significant difference in these parameters between fellow eyes of subjects. In all age groups, the mean endothelial cell density was significantly lower than values reported previously in the Japanese population. The values were less than those described in the American population, but the differences were statistically significant only in the 20-30 and 41-50 year age groups.
Normative data for the endothelium in the Indian population are reported. Endothelial cell density in Indian eyes is less than the values described in the Japanese and American populations.
描述印度人群的角膜内皮细胞密度和形态，并将印度人群的内皮细胞特征与文献中美国和日本人群的数据进行比较。
对537名年龄在20 - 87岁的正常印度志愿者的双眼进行镜面显微镜检查和角膜测厚。研究的参数包括内皮细胞密度、细胞面积、细胞面积变异系数（CV）和六边形细胞比例。
研究人群的平均内皮细胞密度为2525±337个细胞/mm²。内皮细胞密度随年龄增长有统计学显著下降（p < 0.001，相关性为 -0.387），细胞丢失率为每年0.3%。随着年龄增长，平均细胞面积（p < 0.001，相关性为0.362）和CV（p = 0.02，相关性为0.096）也有统计学显著增加，六边形细胞百分比下降（p = 0.01，相关性为 -0.127）。受试者双眼之间这些参数无显著差异。在所有年龄组中，平均内皮细胞密度均显著低于先前报道的日本人群的值。这些值低于美国人群中描述的值，但差异仅在20 - 30岁和41 - 50岁年龄组中有统计学显著性。
报告了印度人群内皮的标准数据。印度人眼睛的内皮细胞密度低于日本和美国人群中描述的值。
