Mohammad-Salih P A K
Department of Ophthalmology, Faculty of Medicine, Istana Bandar Indera Mahkota, 25200 Kuantan, Malaysia.
Med J Malaysia. 2011 Oct;66(4):300-3.
This study was conducted to describe corneal endothelial cell density and morphology in Malay eyes. Non-contact specular microscopy was performed in 125 eyes of 125 Malay volunteers, aged 20-87 years. Studied parameters included endothelial cell density (CD), mean cell area (MCA), coefficient of variation (CV) in cell area, as well as hexagonal appearance of the cells. Mean endothelial cell density in the study population was 2648 +/- 310 cell/mm(2). Mean CA, CV and percentage of hexagonal cells were 382.8 +/- 47.7microm(2), 58.1 +/- 22.6, 44.3% +/- 11.5% respectively. There was a statistically significant decrease in endothelial cell density (correlation - 0.300, P = 0.001) and CV in cell size (correlation - 0.208, P = 0.02) with age. There was a statistically significant increase in mean cell area (correlation 0.300, P = 0.001) with increasing age. The correlation between age and percentage of hexagonal cells was insignificant (correlation 0.074, P = 0.41). In conclusion, a consistent decrease was noted in the endothelial cell density with increasing age. The differences in endothelial cell density between genders were statistically insignificant.
本研究旨在描述马来人眼睛的角膜内皮细胞密度和形态。对125名年龄在20至87岁之间的马来志愿者的125只眼睛进行了非接触式镜面显微镜检查。研究参数包括内皮细胞密度（CD）、平均细胞面积（MCA）、细胞面积变异系数（CV）以及细胞的六边形外观。研究人群的平均内皮细胞密度为2648±310个细胞/mm²。平均细胞面积、CV和六边形细胞百分比分别为382.8±47.7μm²、58.1±22.6、44.3%±11.5%。内皮细胞密度（相关性 - 0.300，P = 0.001）和细胞大小的CV（相关性 - 0.208，P = 0.02）随年龄增长有统计学意义的下降。平均细胞面积随年龄增长有统计学意义的增加（相关性0.300，P = 0.001）。年龄与六边形细胞百分比之间的相关性不显著（相关性0.074，P = 0.41）。总之，随着年龄增长，内皮细胞密度持续下降。性别之间内皮细胞密度的差异无统计学意义。
