Harris S S, Soteriades E, Coolidge J A, Mudgal S, Dawson-Hughes B
Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA.
J Clin Endocrinol Metab. 2000 Nov;85(11):4125-30. doi: 10.1210/jcem.85.11.6962.
This report examines the wintertime vitamin D and PTH status of 308 participants in the Boston Low Income Elderly Osteoporosis Study of noninstitutionalized low income elderly men and women (age, 64-100 yr) living in subsidized housing in Boston, MA. Twenty-one percent of the 136 black subjects and 11% of the 110 whites had very low plasma 25-hydroxyvitamin D (25OHD) concentrations (<25 nmol/L), and 73% of the blacks and 35% of the whites had 25OHD concentrations less than 50 nmol/L. The mean 25OHD levels of the smaller Hispanic and Asian subsets were generally similar to those of the white subjects. In addition to race, significant predictors of 25OHD included vitamin D intake (positive association) and smoking (inverse association), but not sex or age. Low 25OHD concentrations were associated with increased PTH and reduced serum calcium. The PTH level in the black subjects was substantially higher than that in the white subjects, and this difference was only partially explained by the racial difference in 25OHD. Elderly individuals who live in northern areas, particularly African-Americans, should be strongly encouraged to increase their vitamin D intake, especially in winter.
本报告调查了波士顿低收入老年人骨质疏松症研究中308名参与者冬季的维生素D和甲状旁腺激素（PTH）状况。该研究对象为居住在马萨诸塞州波士顿市保障性住房中的非机构化低收入老年男性和女性（年龄64 - 100岁）。136名黑人受试者中有21%、110名白人受试者中有11%的血浆25 - 羟基维生素D（25OHD）浓度极低（<25 nmol/L），73%的黑人及35%的白人25OHD浓度低于50 nmol/L。人数较少的西班牙裔和亚裔亚组的25OHD平均水平总体上与白人受试者相似。除种族外，25OHD的显著预测因素包括维生素D摄入量（正相关）和吸烟（负相关），但与性别或年龄无关。低25OHD浓度与PTH升高和血清钙降低有关。黑人受试者的PTH水平显著高于白人受试者，而这种差异仅部分可由2�OHD的种族差异来解释。应大力鼓励居住在北方地区的老年人，尤其是非裔美国人，增加维生素D摄入量，特别是在冬季。
