Yamamoto S, Hayashi M, Takeuchi S
Department of Ophthalmology, Toho University Sakura Hospital, Chiba, Japan.
Doc Ophthalmol. 1999;99(2):183-9. doi: 10.1023/a:1002730625683.
Cone electroretinograms (ERGs) elicited by different chromatic stimuli were recorded from patients with typical retinitis pigmentosa (RP) younger than 50 years of age. Ganzfeld color flashes on a bright white background illumination were used to elicit short-wavelength-sensitive (S-), and mixed long- (L-) and middle- (M-) wavelength-sensitive cone ERGs. Three patients with dominant inheritance, 22 patients with non-dominant inheritance, and 27 age-similar normal subjects were compared. Although the b-wave amplitudes of both the S- and L,M-cone ERGs were reduced in the RP patients, the S-cones were reduced to a greater degree than the L,M-cones. No significant difference in the S-cone reduction was observed between patients with dominant inheritance and those with non-dominant inheritance. The selective reduction of the S-cone system, reported previously in psychophysical studies, may be attributable not only to the macular region but also to the entire retina.
对年龄小于50岁的典型视网膜色素变性（RP）患者记录了由不同颜色刺激诱发的视锥细胞视网膜电图（ERG）。在明亮的白色背景照明下使用全视野彩色闪光来诱发短波敏感（S-）以及混合的长波（L-）和中波（M-）敏感视锥细胞ERG。比较了3例显性遗传患者、22例非显性遗传患者和27名年龄相仿的正常受试者。虽然RP患者的S-和L、M-视锥细胞ERG的b波振幅均降低，但S-视锥细胞的降低程度大于L、M-视锥细胞。在显性遗传患者和非显性遗传患者之间，未观察到S-视锥细胞减少的显著差异。先前在心理物理学研究中报道的S-视锥细胞系统的选择性减少，可能不仅归因于黄斑区，还归因于整个视网膜。
