一家综合医院中乙型肝炎表面抗原的流行情况及意义
Prevalence and significance of hepatitis B surface antigen in a general hospital.
作者信息
Feinman S V, Krassnitzky O, Sinclair J C, Wrobel D M, Berris B
出版信息
Can Med Assoc J. 1975 Jan 11;112(1):43-5.
Over a 6-month period 2025 patients admitted to New Mount Sinai Hospital, Toronto were screened for hepatitis B surface antigen (HBsAg) by counter-immunoelectrophoresis (CIEP) and radioimmunoassay (RIA). CIEP detected 12 HBsAg-positive patients and RIA 16. RIA is therefore the more sensitive test for HBsAg. Of the 16 patients 2 had liver disease previously diagnosed, 3 had malignant disease and 11 were asymptomatic carriers. Of the 11 carriers all were born in countries where the carrier rate is known to be high. Routine screening of hospital patients on admission is of no value in detecting unsuspected liver disease but is of value in detecting asymptomatic carriers, which is of importance for the patient and his family. Routine screening tests for HBsAg in Canadian hospitals that treat many patients born in countries with a known high HBsAg prevalence is recommended. Routine screening is also recommended in all hospitals in Mediterranean and Asian countries.
在6个月的时间里，对多伦多新西奈山医院收治的2025例患者，采用对流免疫电泳（CIEP）和放射免疫测定（RIA）法筛查乙型肝炎表面抗原（HBsAg）。CIEP检测出12例HBsAg阳性患者，RIA检测出16例。因此，RIA对HBsAg的检测更为灵敏。16例患者中，2例先前已确诊患有肝病，3例患有恶性疾病，11例为无症状携带者。11例携带者均出生于已知携带者率较高的国家。对入院患者进行常规筛查，对于发现未被怀疑的肝病并无价值，但对于发现无症状携带者具有价值，这对患者及其家人都很重要。建议在治疗许多出生于已知HBsAg高流行国家患者的加拿大医院，对HBsAg进行常规筛查。在地中海和亚洲国家的所有医院也建议进行常规筛查。
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