Rosan B, Lamont R J
Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104, USA.
Microbes Infect. 2000 Nov;2(13):1599-607. doi: 10.1016/s1286-4579(00)01316-2.
Dental plaque is a complex biofilm that accumulates on the hard tissues (teeth) in the oral cavity. Although over 500 bacterial species comprise plaque, colonization follows a regimented pattern with adhesion of initial colonizers to the enamel salivary pellicle followed by secondary colonization through interbacterial adhesion. A variety of adhesins and molecular interactions underlie these adhesive interactions and contribute to plaque development and ultimately to diseases such as caries and periodontal disease.
牙菌斑是一种积聚在口腔硬组织（牙齿）上的复杂生物膜。尽管菌斑中有500多种细菌，但细菌的定植遵循一定模式，最初定植菌先黏附于牙釉质表面的唾液薄膜，随后通过细菌间黏附进行二次定植。多种黏附素和分子相互作用构成了这些黏附过程，并促进菌斑形成，最终导致龋齿和牙周病等疾病。
