Cooper R J, Hallett R, Tullo A B, Klapper P E
School of Medicine, The University of Manchester, UK.
Epidemiol Infect. 2000 Oct;125(2):333-45. doi: 10.1017/s0950268899004550.
Data relating to 3313 adenovirus isolates from patients in Greater Manchester, UK between 1982 and 1996 were analysed using chi2 tests and 95% confidence intervals. Of the 3098 isolates that were typed, 18.6% were serotype 2, 14.9% serotype 3, 12.1% serotype 1 and 10.9% serotype 41. There was evidence of a seasonal occurrence of serotype 7 (March-August), serotype 2 (January-April), serotype 4 (June-August) and subgenus F (September-November). Children less than 5 years old were the most common group of patients with adenovirus infection (61.3%) compared to 24.2% for adults and only 5.6% for school children (5-15 years). Gastric symptoms were the most common amongst infants (47.6%) followed by respiratory (27.5%) and general symptoms (12.9%). In adults, the overwhelming clinical condition was conjunctivitis (88.9%). Despite the traditional association with adenoviruses, remarkably few cases of pharyngoconjunctival fever were recorded (1.7%).
对1982年至1996年间英国大曼彻斯特地区患者的3313株腺病毒分离株的数据进行了分析，采用卡方检验和95%置信区间。在3098株分型的分离株中，18.6%为2型血清型，14.9%为3型血清型，12.1%为1型血清型，10.9%为41型血清型。有证据表明7型血清型（3月至8月）、2型血清型（1月至4月）、4型血清型（6月至8月）和F亚属（9月至11月）有季节性发病情况。与成人的24.2%和学龄儿童（5 - 15岁）的仅5.6%相比，5岁以下儿童是腺病毒感染最常见的患者群体（61.3%）。胃部症状在婴儿中最为常见（47.6%），其次是呼吸道症状（27.5%）和一般症状（12.9%）。在成人中，压倒性的临床病症是结膜炎（88.9%）。尽管传统上认为腺病毒与某些疾病有关，但记录到的咽结膜热病例极少（1.7%）。
