Hierholzer J C, Torrence A E, Wright P F
J Infect Dis. 1980 Mar;141(3):281-8. doi: 10.1093/infdis/141.3.281.
Ten isolates of an antigenically intermediate strain of adenovirus were recovered from eight persons who presented febrile upper respiratory illness, pneumonia, or multisystem disease between November 1976 and August 1978. Six isolates were recovered from four members of an extended family in which the other nine members all had serologic evidence of infection; the other four isolates were epidemiologically unrelated. The isolates were placed in hemagglutination group IB on the basis of results of differential hemagglutination tests. All isolates were identified as adenovirus 21 by serum-neutralization tests and as types 21, 34, or 35 by hemagglutination-inhibition tests with reference rabbit and horse antisera. Conversely, rabbit antiserum to the intermediate strain had high titers of neutralizing antibody to adenovirus 21 and high titers of hemagglutination-inhibiting antibody to adenoviruses 21 and 35. The patients' serologic responses were similar. Thus, the isolates were typed as adenovirus 21/H21 + 35 and are the first such intermediate strains recorded.
1976年11月至1978年8月期间，从8名出现发热性上呼吸道疾病、肺炎或多系统疾病的患者中分离出10株抗原性中间型腺病毒。其中6株是从一个大家庭的4名成员中分离出来的，该家庭的其他9名成员均有感染的血清学证据；另外4株在流行病学上无关联。根据鉴别血凝试验结果，这些分离株被归入血凝IB组。通过血清中和试验，所有分离株均被鉴定为腺病毒21型；使用参考兔和马抗血清进行血凝抑制试验，结果显示它们为21型、34型或35型。相反，针对该中间型毒株的兔抗血清对腺病毒21型具有高滴度的中和抗体，对腺病毒21型和35型具有高滴度的血凝抑制抗体。患者的血清学反应相似。因此，这些分离株被分型为腺病毒21/H21 + 35型，是首次记录到的此类中间型毒株。
