Waliszewski S M, Aguirre A A, Infanzón R M, Siliceo J
Instituto de Medicina Forense de la Universidad Veracruzana, Veracruz, Ver., México.
Salud Publica Mex. 2000 Sep-Oct;42(5):384-90. doi: 10.1590/s0036-36342000000500003.
As a consequence of environmental exposure, organochlorine pesticides accumulate in lipid rich-tissues such as maternal adipose tissue and partition to maternal blood serum and umbilical blood serum. To establish their distribution in the human body, the concentration gradients of organochlorine pesticides between these compartments were determined.
Maternal adipose tissue, blood serum and umbilical blood serum samples from 64 volunteers admitted for cesarean delivery at Hospital Benito Coquet Lagunes were studied in Veracruz during 1997 and 1998. The pesticide residues were determined by gas chromatography and results obtained from different sample groups were analyzed using Pearson correlation coefficients and simple lineal regression.
Significant results expressed on fat basis of organochlorine pesticides indicate that 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) levels are higher in maternal adipose tissue (4.51 mg/kg DDE and 1.27 mg/kg pp'DDT), maternal blood serum (4.45 mg/kg DDE and 0.78 mg/kg pp'DDT), and umbilical blood serum (4.70 mg/kg DDE and 0.88 mg/kg pp'DDT), due to greater affinity of DDT for lipids.
The statistical evaluation of results and the pairing of samples analyzed indicate that absorbed organochlorine pesticides cross the placental barrier and reach a balanced state between mother and fetus.
由于环境暴露，有机氯农药会在富含脂质的组织（如母体脂肪组织）中蓄积，并分配到母体血清和脐血血清中。为确定它们在人体中的分布情况，测定了这些隔室之间有机氯农药的浓度梯度。
1997年和1998年在韦拉克鲁斯，对贝尼托·科克·拉古内斯医院因剖宫产入院的64名志愿者的母体脂肪组织、血清和脐血血清样本进行了研究。通过气相色谱法测定农药残留，并使用皮尔逊相关系数和简单线性回归分析不同样本组获得的结果。
以脂肪为基础表示的有机氯农药的显著结果表明，由于滴滴涕对脂质具有更高的亲和力，母体脂肪组织（4.51毫克/千克滴滴滴和1.27毫克/千克对，对'-滴滴涕）、母体血清（4.45毫克/千克滴滴滴和0.78毫克/千克对，对'-滴滴涕）和脐血血清（4.70毫克/千克滴滴滴和0.88毫克/千克对，对'-滴滴涕）中的1,1,1-三氯-2,2-双（4-氯苯基）乙烷（滴滴涕）水平更高。
结果的统计评估以及所分析样本的配对表明，吸收的有机氯农药会穿过胎盘屏障，并在母体和胎儿之间达到平衡状态。
