一种对包括妥布霉素在内的所有非β-内酰胺类抗生素敏感的不寻常耐甲氧西林金黄色葡萄球菌克隆的医院内传播。
Nosocomial spread of an unusual methicillin-resistant Staphylococcus aureus clone that is sensitive to all non-beta-lactam antibiotics, including tobramycin.
作者信息
Pournaras S, Slavakis A, Polyzou A, Sofianou D, Maniatis A N, Tsakris A
机构信息
Department of Microbiology, Hippokration General Hospital, Thessaloniki, Greece.
出版信息
J Clin Microbiol. 2001 Feb;39(2):779-81. doi: 10.1128/JCM.39.2.779-781.2001.
Abstract
Between January and December 1999, in Hippokration General Hospital, Thessaloniki, Greece, a large proportion of the methicillin-resistant Staphylococcus aureus isolates (34.4%) exhibited susceptibility to virtually all alternative non-beta-lactam antibiotics, including tobramycin. Twenty-five of them were selected randomly for further testing; all belonged to a unique genotype and were characterized as heterogeneously resistant to oxacillin. The aadD gene, encoding tobramycin resistance, failed to be amplified in all cases, indicating absence of the gene or the entire plasmid pUB110 from the mec DNA.
摘要
1999年1月至12月期间，在希腊塞萨洛尼基的希波克拉底综合医院，很大一部分耐甲氧西林金黄色葡萄球菌分离株（34.4%）对几乎所有其他非β-内酰胺类抗生素敏感，包括妥布霉素。从中随机选取25株进行进一步检测；所有菌株都属于单一基因型，且对苯唑西林表现为异质性耐药。编码妥布霉素耐药性的aadD基因在所有病例中均未扩增，这表明mec DNA中不存在该基因或整个质粒pUB110。
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2
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3
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10
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