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本文引用的文献

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Genetic organization of the downstream region of the mecA element in methicillin-resistant Staphylococcus aureus isolates carrying different polymorphisms of this region.携带该区域不同多态性的耐甲氧西林金黄色葡萄球菌分离株中mecA元件下游区域的基因组织
Antimicrob Agents Chemother. 2000 Jul;44(7):1906-10. doi: 10.1128/AAC.44.7.1906-1910.2000.
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Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis.多重聚合酶链反应检测确定的耐药基因型与金黄色葡萄球菌和表皮葡萄球菌抗生素敏感性模式之间的相关性。
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Phenotypic and molecular typing of nosocomial methicillin-resistant Staphylococcus aureus strains susceptible to gentamicin isolated in france from 1995 to 1997.1995年至1997年在法国分离出的对庆大霉素敏感的医院内耐甲氧西林金黄色葡萄球菌菌株的表型和分子分型
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Emergence and spread in French hospitals of methicillin-resistant Staphylococcus aureus with increasing susceptibility to gentamicin and other antibiotics.耐甲氧西林金黄色葡萄球菌在法国医院中的出现及传播,同时其对庆大霉素和其他抗生素的敏感性增加。
J Clin Microbiol. 1999 Nov;37(11):3452-7. doi: 10.1128/JCM.37.11.3452-3457.1999.
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Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315.耐甲氧西林金黄色葡萄球菌N315前体的完整mec DNA的克隆及核苷酸序列测定
Antimicrob Agents Chemother. 1999 Jun;43(6):1449-58. doi: 10.1128/AAC.43.6.1449.
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Detection of an archaic clone of Staphylococcus aureus with low-level resistance to methicillin in a pediatric hospital in Portugal and in international samples: relics of a formerly widely disseminated strain?在葡萄牙一家儿科医院及国际样本中检测到一株对甲氧西林具有低水平耐药性的金黄色葡萄球菌古老克隆株:这是一种曾经广泛传播的菌株的遗留物吗?
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Revised guidelines for the control of methicillin-resistant Staphylococcus aureus infection in hospitals. British Society for Antimicrobial Chemotherapy, Hospital Infection Society and the Infection Control Nurses Association.医院耐甲氧西林金黄色葡萄球菌感染控制修订指南。英国抗菌化疗协会、医院感染协会及感染控制护士协会
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Assessment of resolution and intercenter reproducibility of results of genotyping Staphylococcus aureus by pulsed-field gel electrophoresis of SmaI macrorestriction fragments: a multicenter study.通过SmaI酶切大片段脉冲场凝胶电泳对金黄色葡萄球菌进行基因分型的结果分辨率及中心间可重复性评估:一项多中心研究
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Characterization of gentamicin-susceptible strains of methicillin-resistant Staphylococcus aureus involved in nosocomial spread.参与医院传播的耐甲氧西林金黄色葡萄球菌庆大霉素敏感菌株的特征分析。
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Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications.葡萄球菌中的耐甲氧西林特性:分子与生化基础及临床意义
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一种对包括妥布霉素在内的所有非β-内酰胺类抗生素敏感的不寻常耐甲氧西林金黄色葡萄球菌克隆的医院内传播。

Nosocomial spread of an unusual methicillin-resistant Staphylococcus aureus clone that is sensitive to all non-beta-lactam antibiotics, including tobramycin.

作者信息

Pournaras S, Slavakis A, Polyzou A, Sofianou D, Maniatis A N, Tsakris A

机构信息

Department of Microbiology, Hippokration General Hospital, Thessaloniki, Greece.

出版信息

J Clin Microbiol. 2001 Feb;39(2):779-81. doi: 10.1128/JCM.39.2.779-781.2001.

DOI:10.1128/JCM.39.2.779-781.2001
PMID:11158151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC87820/
Abstract

Between January and December 1999, in Hippokration General Hospital, Thessaloniki, Greece, a large proportion of the methicillin-resistant Staphylococcus aureus isolates (34.4%) exhibited susceptibility to virtually all alternative non-beta-lactam antibiotics, including tobramycin. Twenty-five of them were selected randomly for further testing; all belonged to a unique genotype and were characterized as heterogeneously resistant to oxacillin. The aadD gene, encoding tobramycin resistance, failed to be amplified in all cases, indicating absence of the gene or the entire plasmid pUB110 from the mec DNA.

摘要

1999年1月至12月期间,在希腊塞萨洛尼基的希波克拉底综合医院,很大一部分耐甲氧西林金黄色葡萄球菌分离株(34.4%)对几乎所有其他非β-内酰胺类抗生素敏感,包括妥布霉素。从中随机选取25株进行进一步检测;所有菌株都属于单一基因型,且对苯唑西林表现为异质性耐药。编码妥布霉素耐药性的aadD基因在所有病例中均未扩增,这表明mec DNA中不存在该基因或整个质粒pUB110。