在一家波兰医院中携带vanB2基因变体的耐万古霉素屎肠球菌菌株。
Vancomycin-resistant Enterococcus faecium strain carrying the vanB2 gene variant in a Polish hospital.
作者信息
Kawalec M, Gniadkowski M, Zielińska U, Kłos W, Hryniewicz W
机构信息
Sera & Vaccines Central Research Laboratory, 00-725 Warsaw, Poland.
出版信息
J Clin Microbiol. 2001 Feb;39(2):811-5. doi: 10.1128/JCM.39.2.811-815.2001.
Abstract
About 2.5 years after the first isolation of the VanA phenotype of vancomycin-resistant Enterococcus faecium (VREM) in Poland, the first VREM strains with the VanB phenotype have emerged independently in two different Warsaw hospitals. In one of these the VREM strain was selected during the long-term antimicrobial treatment of a patient with a wide variety of infection risk factors who died after 3 months of hospitalization. The strain was found to contain the transferable vanB2 gene cluster variant of the polymorphic type that was identified earlier in vancomycin-resistant enterococci from several different countries. In the course of infection the strain underwent genetic diversification due to DNA recombination.
摘要
在波兰首次分离出耐万古霉素屎肠球菌（VREM）的VanA表型约2.5年后，首批具有VanB表型的VREM菌株在华沙两家不同的医院独立出现。其中一家医院，VREM菌株是在对一名有多种感染风险因素的患者进行长期抗菌治疗期间分离出来的，该患者在住院3个月后死亡。该菌株被发现含有多态型的可转移vanB2基因簇变体，这种变体此前在来自几个不同国家的耐万古霉素肠球菌中已被鉴定出来。在感染过程中，该菌株由于DNA重组而发生了基因多样化。
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