成人哮喘的社会预测因素：一项双胞胎病例对照研究。
Social predictors of adult asthma: a co-twin case-control study.
作者信息
Huovinen E, Kaprio J, Laitinen L A, Koskenvuo M
机构信息
Department of Public Health, University of Helsinki, Finland.
出版信息
Thorax. 2001 Mar;56(3):234-6. doi: 10.1136/thorax.56.3.234.
BACKGROUND
Environmental factors are needed to explain the observed increase in the prevalence of asthma during recent decades, despite the existence of a recognised genetic component in asthma. A co-twin case-control study was undertaken to examine possible social risk factors for asthma.
METHODS
Asthma diagnoses were based on register data of reimbursed asthma medication. During 17 years follow up of the Finnish twin cohort, 262 twin pairs discordant for incident asthma were identified. Conditional logistic regression for 1-1 matched data was used for risk calculation.
RESULTS
The atopic twin had an increased risk of asthma compared with the non-atopic co-twin (RR 2.91, 95% CI 1.81 to 4.68). The more educated twin had a decreased risk of asthma compared with his/her twin sibling with less education (RR 0.45, 95% CI 0.23 to 0.86), and the twin who participated in conditioning exercise had a decreased risk of asthma compared with the more sedentary co-twin (RR 0.55, 95% CI 0.34 to 0.88).
CONCLUSIONS
In addition to allergic diseases, educational level and physical activity are associated with adult onset asthma, which indicates a role for factors associated with life style.
背景
尽管哮喘存在公认的遗传因素，但仍需要环境因素来解释近几十年来观察到的哮喘患病率上升现象。开展了一项双胞胎病例对照研究，以调查哮喘可能的社会风险因素。
方法
哮喘诊断基于报销的哮喘药物登记数据。在对芬兰双胞胎队列进行17年随访期间，确定了262对在哮喘发病情况上不一致的双胞胎。对1-1匹配数据使用条件逻辑回归进行风险计算。
结果
与非特应性双胞胎相比，特应性双胞胎患哮喘的风险增加（相对危险度2.91，95%可信区间1.81至4.68）。与受教育程度较低的双胞胎兄弟姐妹相比，受教育程度较高的双胞胎患哮喘的风险降低（相对危险度0.45，95%可信区间0.23至0.86），与久坐不动的双胞胎相比，参加适应性锻炼的双胞胎患哮喘的风险降低（相对危险度0.55，95%可信区间0.34至0.88）。
结论
除过敏性疾病外，教育水平和体育活动与成人期哮喘有关，这表明生活方式相关因素起了作用。
Zotero 插件