Lee J B, Srisomporn P, Hayashi K, Tanaka T, Sankawa U, Hayashi T
Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo). 2001 Jan;49(1):108-10. doi: 10.1248/cpb.49.108.
Calcium ion binding with the anionic part of a molecule was replaced with various metal cations and their inhibitory effects on the replication of herpes simplex virus type 1 were evaluated. Replacement of calcium ion with sodium and potassium ions maintained the antiviral activity while divalent and trivalent metal cations reduced the activity. Depolymerization of sodium spirulan with hydrogen peroxide decreased in antiviral activity as its molecular weight decreased.
用各种金属阳离子取代与分子阴离子部分结合的钙离子，并评估它们对1型单纯疱疹病毒复制的抑制作用。用钠离子和钾离子取代钙离子可保持抗病毒活性，而二价和三价金属阳离子则降低活性。随着分子量的降低，用过氧化氢使螺旋藻酸钠解聚，其抗病毒活性降低。
