Simonsen Henrik T, Adsersen Anne, Berthelsen Louise, Christensen Søren B, Guzmán Alfonso, Mølgaard Per
Department of Plant Biology, Royal Veterinary and Agricultural University, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.
BMC Complement Altern Med. 2006 Aug 31;6:29. doi: 10.1186/1472-6882-6-29.
Leaves of Lomatia hirsuta are used in traditional medicine in Chile under the common name of "radal". A tea of radal is traditionally used for treatment of cough, bronchial troubles, and asthma. In a preliminary screening, extracts of the leaves revealed antifungal activity, and the present phytochemical study was undertaken to explain this activity and support the traditional use.
Along with the traditional tea, extracts of the leaves were screened for antifungal and toxic activities. The profile of secondary constituents was obtained using GC-MS.
2-Methoxyjuglone was isolated from the leaves of Lomatia hirsuta and found to be active against the pathogenic fungus Candida albicans (MIC = 8 microg/mL). Cinnamic acid and vanillic acid were identified as major constituents in the tea by GC-MS. The tea was found not to be toxic against Artemia salina.
The presence of phenolic acids with antimicrobial properties supports the traditional use of Radal, and encourages further studies.
智利传统医学中使用多毛洛玛希亚叶，其通用名为“拉达尔”。传统上，拉达尔茶用于治疗咳嗽、支气管疾病和哮喘。在初步筛选中，叶提取物显示出抗真菌活性，因此开展了本植物化学研究以解释这种活性并支持其传统用途。
除了传统茶外，还对叶提取物进行了抗真菌和毒性活性筛选。使用气相色谱 - 质谱联用仪（GC-MS）获得次生成分概况。
从多毛洛玛希亚叶中分离出2-甲氧基胡桃醌，发现其对致病性真菌白色念珠菌有活性（最低抑菌浓度=8微克/毫升）。通过GC-MS鉴定肉桂酸和香草酸为茶中的主要成分。发现该茶对卤虫无毒。
具有抗菌特性的酚酸的存在支持了拉达尔的传统用途，并鼓励进一步研究。
