Paquet P, Hermanns J F, Piérard G E
Department of Dermatopathology, Belgian SSTC Research Center, University Medical Center Sart Tilman,Liège, Belgium.
Dermatol Surg. 2001 Feb;27(2):171-4. doi: 10.1046/j.1524-4725.2001.00169.x.
Due to its potential effects on skin microcirculation and collagen metabolism, the 585 nm flashlamp-pumped pulsed dye laser has been proposed for treating abnormal scars. Indeed, one of the main problems with keloidal scars is their disfiguring erythematous color.
To assess the efficacy of the 585 nm pulsed dye laser on the appearance of keloids.
Eleven patients with skin phototypes II-IV and keloids were treated with the 585 nm pulsed dye laser. After one to three treatment sessions, clinical assessments of the scars were performed in combination with remittance spectroscopy measurements of the redness and melanin pigmentation. A group of nine keloids covered by silicone gel sheeting served as controls. Data were compared statistically.
During laser treatments, a discrete decrease in redness of the scars was clinically reported. However, this improvement was not confirmed by the objective spectrophotometric data. No side effects, especially hyperpigmentation, were disclosed. The keloids redness was not improved in the control group.
The 585 nm pulsed dye laser yields only minimal effects, if any, on the erythema of keloids. Similarly silicone gel sheeting does not modify the keloids redness.
由于其对皮肤微循环和胶原蛋白代谢的潜在影响,有人提出用585纳米闪光灯泵浦脉冲染料激光治疗异常瘢痕。事实上,瘢痕疙瘩的主要问题之一是其毁容性的红斑颜色。
评估585纳米脉冲染料激光对瘢痕疙瘩外观的疗效。
对11例皮肤光类型为II - IV型且患有瘢痕疙瘩的患者使用585纳米脉冲染料激光进行治疗。在一至三次治疗疗程后,结合对红斑和黑色素沉着的反射光谱测量对瘢痕进行临床评估。一组9例覆盖硅胶片的瘢痕疙瘩作为对照。对数据进行统计学比较。
在激光治疗期间,临床报告瘢痕的红斑有明显减轻。然而,客观分光光度数据并未证实这种改善。未发现副作用,尤其是色素沉着。对照组瘢痕疙瘩的红斑没有改善。
585纳米脉冲染料激光对瘢痕疙瘩的红斑即使有影响也微乎其微。同样,硅胶片也不会改变瘢痕疙瘩的红斑情况。