Bastardo Y M, Kimberlin C L
Department of Pharmacy Health Care Administration, University of Florida, Gainesville, Florida, USA.
AIDS Care. 2000 Oct;12(5):673-84. doi: 10.1080/095401200750003842.
This study examines the relationships among health-related quality of life (HRQL), social support, sociodemographic factors and disease-related factors in persons infected with the human immunodeficiency virus (HIV) living in Venezuela. A sample of 118 HIV-infected persons living in Caracas, Venezuela, was surveyed using a written questionnaire that included a Spanish translation of the Interpersonal Support Evaluation List (ISEL) developed for this study, the Medical Outcomes Study Short Form-36 (SF-36) and a symptom inventory. All three instruments showed good internal consistency reliability. Multiple regression analyses were used to model SF-36 sub-scale scores as a function of symptoms, social support, HIV-status and use of antiretroviral drugs. The models explained between 16 and 39% of the variance in the different HRQL domains. Controlling for other variables in the model, level of symptomatology was significantly associated with all HRQL domains except social functioning and role-emotional scores. Social support was significantly associated with all HRQL domains except physical functioning and bodily pain. The use of antiretroviral drugs was significantly associated with social functioning. The study indicates the importance of social support to the quality of life of HIV-infected individuals in this culture.
本研究探讨了委内瑞拉感染人类免疫缺陷病毒（HIV）的人群中，健康相关生活质量（HRQL）、社会支持、社会人口学因素和疾病相关因素之间的关系。采用书面问卷对委内瑞拉加拉加斯的118名HIV感染者进行了调查，问卷包括为本研究开发的人际支持评估清单（ISEL）的西班牙语译本、医学结局研究简表36（SF-36）和症状清单。所有这三种工具都显示出良好的内部一致性信度。使用多元回归分析将SF-36分量表得分建模为症状、社会支持、HIV状态和抗逆转录病毒药物使用情况的函数。这些模型解释了不同HRQL领域中16%至39%的方差。在控制模型中的其他变量后，症状水平与除社会功能和角色情感得分外的所有HRQL领域均显著相关。社会支持与除身体功能和身体疼痛外的所有HRQL领域均显著相关。抗逆转录病毒药物的使用与社会功能显著相关。该研究表明，在这种文化背景下，社会支持对HIV感染者生活质量的重要性。
