Ishi K, Suzuki F, Saito A, Kubota T
Department of Clinical Pathology, Juntendo University, Urayasu Hospital, Chiba, Japan.
Infect Dis Obstet Gynecol. 2000;8(5-6):235-9. doi: 10.1155/S106474490000034X.
We used the hybrid capture assays to investigate the prevalence of human papillomavirus (HPV), Chlamydia trachomatis and Neisseria gonorrhoeae among commercial sex workers in Tokyo.
Five hundred forty-six consecutive commercial sex workers (CSW) who visited an STD clinic for STD checkup in 1998 and 1999 were studied. A control group consisted of 233 consecutive women who visited a general gynecological clinic for annual checkup. A cervical sample was obtained for hybrid capture assays for HPV-A (low-oncogenic-risk types), HPV-B (intermediate- and high-oncogenic-risk types), C. trachomatis, and N. gonorrhoeae. Fisher's exact test was used for statistical analyses.
The positive rate for HPV-B among the CSW was 48.4%, significantly higher than the 6.0% among the control subjects. The positive rates for HPV-A, C. trachomatis, and N. gonorrhoeae were also significantly higher among the CSW than among the control subjects. Among the microorganisms tested, the positive rate for HPV-B was the highest in both the STD and control groups.
The high prevalence of HPV, C. trachomatis, and N. gonorrhoeae infection in CSW poses a risk of further transmission of STD to the general public, suggesting the need for further education and screening for CSW and the general public. We found high- and intermediate-oncogenic-type HPV to be the most prevalent infection among both CSW and control subjects. Screening for HPV may be necessary in STD and general clinics to predict the risk of cervical malignancy. Hybrid capture assays, which permit simultaneous detection of HPV and other STD with high sensitivity, may be a useful diagnostic method.
我们采用杂交捕获检测法调查东京性工作者中人类乳头瘤病毒（HPV）、沙眼衣原体及淋病奈瑟菌的感染率。
对1998年和1999年到性病门诊进行性病检查的546名连续性工作者进行研究。对照组由233名到普通妇科门诊进行年度检查的连续性工作的女性组成。采集宫颈样本进行HPV-A（低致癌风险型）、HPV-B（中、高致癌风险型）、沙眼衣原体及淋病奈瑟菌的杂交捕获检测。采用Fisher精确检验进行统计学分析。
性工作者中HPV-B的阳性率为48.4%，显著高于对照组的6.0%。性工作者中HPV-A、沙眼衣原体及淋病奈瑟菌的阳性率也显著高于对照组。在检测的微生物中，HPV-B在性病组和对照组中的阳性率均最高。
性工作者中HPV、沙眼衣原体及淋病奈瑟菌的高感染率存在将性病进一步传播给普通人群的风险，提示有必要对性工作者及普通人群进行进一步教育和筛查。我们发现高危和中危型HPV在性工作者和对照组中都是最普遍的感染类型。在性病门诊和普通诊所筛查HPV对于预测宫颈癌风险可能是必要的。能够同时高灵敏度检测HPV和其他性病的杂交捕获检测法可能是一种有用的诊断方法。
