Vandesande F, Dierickx K, DeMey J
Cell Tissue Res. 1975;156(2):189-200. doi: 10.1007/BF00221802.
Immuno-enzyme histochemical investigations on the bovine hypothalamus showed that vasopressin and oxytocin are synthetized in separate neurons. Moreover, it was found that the vasopressin-producing neurons are identical with the neruophysin II-producing neurons, while the oxtocin producing neurons correspond with the neurophysin I-producing neurons. From this result it is concluded that, in the species studied, neurophysin I is the carrier protein of oxytocin and that neurophysin II is the carrier protein of vasopressin. The bovine vasopressin-neurophysin II producing neurons and the oxytocin-neurophysin I producing neurons are both present as well in the suparoptic nuclei as in the paraventricular nuclei. In the supraoptic nuclei, the vasopressin-neurophysin II neurons predominate in number; in the paraventricular nuclei, the oxytocin-neurophysin II neurons predominate. The two kinds of bovine neurosecretory neurons are partly localized in separate areas. Moreover, the vasopressin-neurophysin II neurons and the oxytocin-neurophysin I neurons show distinct morphological differences.
对牛下丘脑进行的免疫酶组织化学研究表明，血管加压素和催产素是在不同的神经元中合成的。此外，还发现产生血管加压素的神经元与产生神经垂体素II的神经元相同，而产生催产素的神经元与产生神经垂体素I的神经元相对应。从这一结果可以得出结论，在所研究的物种中，神经垂体素I是催产素的载体蛋白，神经垂体素II是血管加压素的载体蛋白。产生牛血管加压素-神经垂体素II的神经元和产生催产素-神经垂体素I的神经元在视上核和室旁核中均有存在。在视上核中，产生血管加压素-神经垂体素II的神经元数量占优势；在室旁核中，产生催产素-神经垂体素I的神经元占优势。牛的这两种神经分泌神经元部分位于不同区域。此外，产生血管加压素-神经垂体素II的神经元和产生催产素-神经垂体素I的神经元表现出明显的形态差异。
