戊二醛溶液的杀分枝杆菌活性
Mycobactericidal activity of glutaraldehyde solutions.
作者信息
Collins F M, Montalbine V
出版信息
J Clin Microbiol. 1976 Nov;4(5):408-12. doi: 10.1128/jcm.4.5.408-412.1976.
Abstract
Aqueous solutions of alkaline glutaraldehyde (buffered at pH 8.5) inactivated a standard suspension of Mycobacterium tuberculosis H37Rv faster than the corresponding acid (pH 3.7 preparation. Quantitative differences in the rate of inactivation of eight other species of Mycobacterium were determined using a 1% solution of alkaline glutaraldehyde and inactivation of residual glutaraldehyde with 1% sodium bisulfite solution. Variations in the rate of kill were observed between the various mycobacterial species tested, but such differences were probably not sufficiently large to be of practical importance. A 2% alkaline glutaraldehyde solution inactivated 10(5) viable M. tuberculosis cells present on the surface of porcelain penicylinders within 5 min at 18 degrees C. This rate of inactivation was faster than in the acidic solution.
摘要
碱性戊二醛水溶液（pH 8.5缓冲）比相应的酸性（pH 3.7）制剂更快地灭活结核分枝杆菌H37Rv的标准悬液。使用1%碱性戊二醛溶液和用1%亚硫酸氢钠溶液灭活残留戊二醛，测定了其他八种分枝杆菌的灭活速率的定量差异。在所测试的各种分枝杆菌菌种之间观察到杀灭速率的变化，但这种差异可能不够大，没有实际重要性。2%碱性戊二醛溶液在18℃下5分钟内灭活了瓷质青霉素瓶表面存在的10⁵个活结核分枝杆菌细胞。这种灭活速率比在酸性溶液中更快。
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