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通过对古细菌RNA的比较分析对核糖核酸酶P RNA结构的新见解。

New insight into RNase P RNA structure from comparative analysis of the archaeal RNA.

作者信息

Harris J K, Haas E S, Williams D, Frank D N, Brown J W

机构信息

Department of Microbiology, North Carolina State University, Raleigh 27695, USA.

出版信息

RNA. 2001 Feb;7(2):220-32. doi: 10.1017/s1355838201001777.

Abstract

A detailed comparative analysis of archaeal RNase P RNA structure and a comparison of the resulting structural information with that of the bacterial RNA reveals that the archaeal RNase P RNAs are strikingly similar to those of Bacteria. The differences between the secondary structure models of archaeal and bacterial RNase P RNA have largely disappeared, and even variation in the sequence and structure of the RNAs are similar in extent and type. The structure of the cruciform (P7-11) has been reevaluated on the basis of a total of 321 bacterial and archaeal sequences, leading to a model for the structure of this region of the RNA that includes an extension to P11 that consistently organizes the cruciform and adjacent highly-conserved sequences.

摘要

对古细菌核糖核酸酶P RNA结构进行详细的比较分析,并将所得结构信息与细菌RNA的结构信息进行比较,结果表明古细菌核糖核酸酶P RNA与细菌的核糖核酸酶P RNA惊人地相似。古细菌和细菌核糖核酸酶P RNA二级结构模型之间的差异已基本消失,甚至RNA序列和结构的变化在程度和类型上也相似。基于总共321个细菌和古细菌序列,对十字形结构(P7 - 11)的结构进行了重新评估,得出了该RNA区域的结构模型,该模型包括延伸至P11的部分,该部分一致地组织了十字形结构和相邻的高度保守序列。

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