Lodén M, Bárány E
ACO Hud AB, Upplands Väsby, Sweden.
Acta Derm Venereol. 2000 Nov-Dec;80(6):412-5. doi: 10.1080/000155500300012774.
The cutaneous permeability barrier is localized to the stratum corneum interstices and is mediated by lamellar bilayers enriched in cholesterol, free fatty acids and ceramides. Topically applied lipids may interfere with the skin barrier function and formulations containing "skin-identical lipids" have been suggested to facilitate normalization of damaged skin. The aim of the present study was to compare the ability of "skin-identical lipids" in a petrolatum-rich cream base and pure petrolatum to facilitate barrier repair in detergent- and tape-stripped-perturbed human skin. Barrier recovery and inflammation were instrumentally monitored for 14 days as transepidermal water loss and skin blood flow, using an Evaporimeter and a laser Doppler flowmeter, respectively. Treatment with the 2 different products gave no indication that "skin-identical lipids" in a cream base are more efficient than pure petrolatum at promoting normalization in either of the 2 experimentally perturbed areas. This finding may support the hypothesis that different types of skin abnormality should be treated according to the underlying damage.
皮肤渗透屏障定位于角质层间隙，由富含胆固醇、游离脂肪酸和神经酰胺的板层双分子层介导。局部应用的脂质可能会干扰皮肤屏障功能，有人提出含有“皮肤相似脂质”的配方有助于受损皮肤恢复正常。本研究的目的是比较富含凡士林的乳膏基质中的“皮肤相似脂质”和纯凡士林促进去污剂和胶带剥离扰动的人体皮肤屏障修复的能力。分别使用蒸发仪和激光多普勒血流仪，以经表皮水分流失和皮肤血流为指标，对屏障恢复和炎症进行了14天的仪器监测。用这两种不同产品进行的治疗没有表明乳膏基质中的“皮肤相似脂质”在促进两个实验性扰动区域中的任何一个恢复正常方面比纯凡士林更有效。这一发现可能支持这样一种假设，即不同类型的皮肤异常应根据潜在损伤进行治疗。
