Sharghi N, Schantz P M, Caramico L, Ballas K, Teague B A, Hotez P J
Medical Helminthology Laboratory, Department of Epidemiology and Public Health, Yale Children's Research Center, Yale University School of Medicine, New Haven, CT, USA.
Clin Infect Dis. 2001 Apr 1;32(7):E111-6. doi: 10.1086/319593. Epub 2001 Mar 19.
The zoonotic ascarid Toxocara has been suggested as a possible etiologic agent of asthma. We conducted a clinic-based case-control study to examine whether the zoonotic infection acquired by ingesting Toxocara eggs is associated with asthma in children. Blood samples were collected from children aged 2-15 years, 95 of whom had asthma and 229 of whom did not have asthma. Risk factors for asthma and Toxocara infection were assessed by a questionnaire given to each child's parent or legal guardian. Blood samples were tested for the presence of Toxocara antibodies, using an enzyme-linked immunosorbent assay. No significant association was found between Toxocara infection and asthma. Significant associations were found between asthma and risk factors and between Toxocara infection and risk factors. High prevalence of Toxocara infection was noted among Hispanic children of Puerto Rican descent.
有人提出，人兽共患蛔虫弓首蛔虫可能是哮喘的一种病因。我们开展了一项基于诊所的病例对照研究，以调查因摄入弓首蛔虫卵而获得的人兽共患感染是否与儿童哮喘有关。采集了2至15岁儿童的血样，其中95名患有哮喘，229名未患哮喘。通过向每个孩子的父母或法定监护人发放问卷，评估哮喘和弓首蛔虫感染的危险因素。使用酶联免疫吸附测定法检测血样中是否存在弓首蛔虫抗体。未发现弓首蛔虫感染与哮喘之间存在显著关联。在哮喘与危险因素之间以及弓首蛔虫感染与危险因素之间发现了显著关联。在波多黎各裔的西班牙裔儿童中，弓首蛔虫感染的患病率很高。
