Shimizu C, Kubo M, Takano K, Takano A, Kijima H, Saji H, Katsuyama I, Sasano H, Koike T
Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.
Clin Endocrinol (Oxf). 2001 Mar;54(3):405-10. doi: 10.1046/j.1365-2265.2001.01082.x.
A 35-year-old Japanese woman presented with a phaeochromocytoma and demonstrated marked inflammatory reactions and pyrexia as a result of excessive production of interleukin-6 (IL-6) by the tumour. Serum IL-6 level was 262 ng/l (normal; < 4.0 ng/l). Fever and inflammatory markers were largely overcome by the administration of the nonsteroidal anti-inflammatory drug, naproxen, and all symptoms disappeared soon after the tumour was excised. Immunohistochemical study revealed positive staining using an antihuman IL-6 antibody and Northern analysis showed increased IL-6 mRNA levels in the tumour. Cultured tumour cells showed IL-6 protein synthesis, and nonsteroidal anti-inflammatory drugs such as naproxen and indomethacin directly inhibited IL-6 release. These results indicate that the effects of naproxen in vivo were due, at least in part, to direct suppression of IL-6 secretion from the tumour.
一名35岁的日本女性患有嗜铬细胞瘤，并因肿瘤过度产生白细胞介素-6（IL-6）而出现明显的炎症反应和发热。血清IL-6水平为262 ng/l（正常范围；<4.0 ng/l）。非甾体抗炎药萘普生的使用在很大程度上缓解了发热和炎症指标，肿瘤切除后所有症状很快消失。免疫组织化学研究显示，使用抗人IL-6抗体呈阳性染色，Northern分析显示肿瘤中IL-6 mRNA水平升高。培养的肿瘤细胞显示有IL-6蛋白合成，萘普生和吲哚美辛等非甾体抗炎药可直接抑制IL-6释放。这些结果表明，萘普生在体内的作用至少部分是由于直接抑制了肿瘤IL-6的分泌。
