Frühwirth M, Karmaus W, Moll-Schüler I, Brösl S, Mutz I
Department of Paediatrics, Innsbruck University Hospital, Anichstrasse 35, A-6020 Innsbruck, Austria.
Arch Dis Child. 2001 May;84(5):393-7. doi: 10.1136/adc.84.5.393.
To examine the disease burden and epidemiology of community acquired rotavirus gastroenteritis in Austrian children treated in a paediatric practice.
A prospective, population based, multicentre study in four paediatric practices and two children's hospitals (Innsbruck and Leoben). Children </= 48 months of age presenting with gastroenteritis during a six month period of rotavirus peak between December 1997 and May 1998 were included. Prospective testing of stool samples for rotavirus was performed using ELISA.
A total of 6969 children were enrolled; 171 (2.4%) had community acquired gastroenteritis. Of 144 children who could be included in further analysis, 49 (34%; median age 16.7 months) were rotavirus positive, and 95 (66%; median age 17.0 months) were rotavirus negative. Three of the rotavirus positive children (median age 14.6 months) were hospitalised. The severity of rotavirus positive gastroenteritis was significantly higher than that of rotavirus negative gastroenteritis. The incidence of community acquired gastroenteritis was 4.67 per 100 children per year, and of rotavirus positive gastroenteritis 1.33 per 100 children per year.
Rotavirus is a relevant cause of community acquired gastroenteritis in children aged 4 years and younger treated by a paediatrician. The data can be used as a basis for developing strategies to prevent infection.
研究在儿科诊所接受治疗的奥地利儿童社区获得性轮状病毒肠胃炎的疾病负担和流行病学情况。
在四家儿科诊所和两家儿童医院（因斯布鲁克和莱奥本）开展一项基于人群的前瞻性多中心研究。纳入1997年12月至1998年5月轮状病毒流行高峰期六个月内出现肠胃炎症状、年龄≤48个月的儿童。使用酶联免疫吸附测定法对粪便样本进行轮状病毒的前瞻性检测。
共纳入6969名儿童；171名（2.4%）患有社区获得性肠胃炎。在可纳入进一步分析的144名儿童中，49名（34%；中位年龄16.7个月）轮状病毒检测呈阳性，95名（66%；中位年龄17.0个月）轮状病毒检测呈阴性。3名轮状病毒阳性儿童（中位年龄14.6个月）住院治疗。轮状病毒阳性肠胃炎的严重程度显著高于轮状病毒阴性肠胃炎。社区获得性肠胃炎的发病率为每年每100名儿童4.67例，轮状病毒阳性肠胃炎的发病率为每年每100名儿童1.33例。
轮状病毒是儿科医生治疗的4岁及以下儿童社区获得性肠胃炎的一个相关病因。这些数据可作为制定预防感染策略的依据。
