Justo G Z, Silva M R, Queiroz M L
Department of Pharmacology and Hemocentre, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), SP, Brazil.
Immunopharmacol Immunotoxicol. 2001 Feb;23(1):119-32. doi: 10.1081/iph-100102573.
Chlorella vulgaris extract (CVE) was examined for its effects on the Ehrlich ascites tumor-induced suppression in the numbers of bone marrow and spleen granulocyte-macrophage progenitor cells (CFU-GM) in mice. No effects on bone marrow and spleen CFU-GM, as compared to controls, were observed in normal mice given 50, 100 and 200 mg/kg CVE orally for 5 days. In tumor-bearing mice, myelosuppression concomitant with increased number of spleen CFU-GM were observed. The number of CFU-GM in the bone marrow was restored to control levels after the administration of CVE (50, 100 and 200 mg/kg) to tumor-bearing mice, and a slight reduction in spleen colony formation was observed in these animals. In addition, CVE significantly prolonged the survival of mice inoculated with the Ehrlich ascites tumor. These results suggest a protective antitumor effect of CVE which might be attributable, at least in part, to the stimulation of the production and, possibly, maturation of granulocytes and macrophages.
研究了普通小球藻提取物（CVE）对艾氏腹水瘤诱导的小鼠骨髓和脾脏粒细胞-巨噬细胞祖细胞（CFU-GM）数量抑制的影响。给正常小鼠口服50、100和200mg/kg CVE，持续5天，与对照组相比，未观察到对骨髓和脾脏CFU-GM有影响。在荷瘤小鼠中，观察到骨髓抑制并伴有脾脏CFU-GM数量增加。给荷瘤小鼠施用CVE（50、100和200mg/kg）后，骨髓中的CFU-GM数量恢复到对照水平，并且在这些动物中观察到脾脏集落形成略有减少。此外，CVE显著延长了接种艾氏腹水瘤小鼠的存活时间。这些结果表明CVE具有保护性抗肿瘤作用，这可能至少部分归因于对粒细胞和巨噬细胞产生以及可能的成熟的刺激。
