Cullum N, Nelson E A, Flemming K, Sheldon T
Department of Health Studies, University of York, UK.
Health Technol Assess. 2001;5(9):1-221. doi: 10.3310/hta5090.
Chronic wounds such as leg ulcers, diabetic foot ulcers and pressure sores are common in both acute and community healthcare settings. The prevention and treatment of these wounds involves many strategies: pressure-relieving beds, mattresses and cushions are universally used as measures for the prevention and treatment of pressure sores; compression therapy in a variety of forms is widely used for venous leg ulcer prevention and treatment; and a whole range of therapies involving laser, ultrasound and electricity is also applied to chronic wounds. This report covers the final three reviews from a series of seven.
To assess the clinical effectiveness and cost- effectiveness of: (1) pressure-relieving beds, mattresses and cushions for pressure sore prevention and treatment; (2) compression therapy for the prevention and treatment of leg ulcers; (3) low-level laser therapy, therapeutic ultrasound, electrotherapy and electromagnetic therapy for the treatment of chronic wounds. METHODS - DATA SOURCES: Nineteen electronic databases, including MEDLINE, CINAHL, EMBASE and the Cochrane Controlled Trials Register (CENTRAL), were searched. Relevant journals, conference proceedings and bibliographies of retrieved papers were handsearched. An expert panel was also consulted.
METHODS - STUDY SELECTION: Randomised controlled trials (RCTs) which evaluated these interventions were eligible for inclusion in this review if they used objective measures of outcome such as wound incidence or healing rates. RESULTS - BEDS, MATTRESSES AND CUSHIONS FOR PRESSURE SORE PREVENTION AND TREATMENT: A total of 45 RCTs were identified, of which 40 compared different mattresses, mattress overlays and beds. Only two trials evaluated cushions, one evaluated the use of sheepskins, and two looked at turning beds/kinetic therapy. RESULTS - COMPRESSION FOR LEG ULCERS: A total of 24 trials reporting 26 comparisons were included (two of prevention and 24 of treatment strategies). RESULTS - LOW-LEVEL LASER THERAPY, THERAPEUTIC ULTRASOUND, ELECTROTHERAPY AND ELECTROMAGNETIC THERAPY: Four RCTs of laser (for venous leg ulcers), 10 of therapeutic ultrasound (for pressure sores and venous leg ulcers), 12 of electrotherapy (for ischaemic and diabetic ulcers, and chronic wounds generally) and five of electromagnetic therapy (for venous leg ulcers and pressure sores) were included. Studies were generally small, and of poor methodological quality. CONCLUSIONS (1) Foam alternatives to the standard hospital foam mattress can reduce the incidence of pressure sores in people at risk, as can pressure-relieving overlays on the operating table. One study suggests that air-fluidised therapy may increase pressure sore healing rates. (2) Compression is more effective in healing venous leg ulcers than is no compression, and multi-layered high compression is more effective than single-layer compression. High-compression hosiery was more effective than moderate compression in preventing ulcer recurrence. (3) There is generally insufficient reliable evidence to draw conclusions about the contribution of laser therapy, therapeutic ultrasound, electrotherapy and electromagnetic therapy to chronic wound healing.
慢性伤口,如腿部溃疡、糖尿病足溃疡和压疮,在急性和社区医疗环境中都很常见。这些伤口的预防和治疗涉及多种策略:减压床、床垫和坐垫被广泛用作预防和治疗压疮的措施;各种形式的加压疗法被广泛用于预防和治疗腿部静脉溃疡;一系列涉及激光、超声和电的疗法也应用于慢性伤口。本报告涵盖了七项系列综述中的最后三项。
评估以下方面的临床疗效和成本效益:(1)用于预防和治疗压疮的减压床、床垫和坐垫;(2)用于预防和治疗腿部溃疡的加压疗法;(3)用于治疗慢性伤口的低强度激光疗法、治疗性超声、电疗法和电磁疗法。
方法 - 数据来源:检索了19个电子数据库,包括MEDLINE、CINAHL、EMBASE和Cochrane对照试验注册库(CENTRAL)。对手检了相关期刊、会议论文集和检索论文的参考文献。还咨询了一个专家小组。
方法 - 研究选择:如果随机对照试验(RCT)使用伤口发生率或愈合率等客观结局指标来评估这些干预措施,则有资格纳入本综述。
结果 - 用于预防和治疗压疮的床、床垫和坐垫:共识别出45项RCT,其中40项比较了不同的床垫、床垫衬垫和床。只有两项试验评估了坐垫,一项评估了羊皮垫的使用,两项研究了翻身床/动力疗法。
结果 - 用于腿部溃疡的加压疗法:共纳入24项试验,报告了26项比较(两项预防和24项治疗策略)。
结果 - 低强度激光疗法、治疗性超声、电疗法和电磁疗法:纳入了四项激光(用于腿部静脉溃疡)、十项治疗性超声(用于压疮和腿部静脉溃疡)、十二项电疗法(用于缺血性和糖尿病溃疡以及一般慢性伤口)和五项电磁疗法(用于腿部静脉溃疡和压疮)的RCT。研究一般规模较小,方法学质量较差。
(1)标准医院泡沫床垫的替代泡沫可降低高危人群压疮的发生率,手术台上的减压衬垫也可如此。一项研究表明,气悬浮疗法可能提高压疮的愈合率。(2)加压治疗腿部静脉溃疡比不进行加压更有效,多层高压力加压比单层加压更有效。高压力弹力袜在预防溃疡复发方面比中压力弹力袜更有效。(3)一般没有足够可靠的证据来得出关于激光疗法、治疗性超声、电疗法和电磁疗法对慢性伤口愈合贡献的结论。