Williams D N, Crossley K, Hoffman C, Sabath L D
Antimicrob Agents Chemother. 1975 Feb;7(2):153-8. doi: 10.1128/AAC.7.2.153.
Parenteral clindamycin was evaluated in 41 patients with a variety of infections. The four major findings were as follows. (i) Five hours after the intravenous administration of 600 mg of clindamycin, the mean serum concentration in patients with "moderate to severe" hepatic dysfunction was 24.3 mug/ml, and in those with normal liver function it was 8.3 mug/ml (P < 0.02). This suggests that the dose of clindamycin might be modified in patients with liver disease. (ii) There was a positive association between the 5-h serum clindamycin level and the degree of elevation of the serum glutamic oxaloacetic transaminase. (iii) No significant side effects were observed. Of 24 patients with preexisting hepatic dysfunction, 5 showed deterioration and 5 showed improvement of liver function during therapy. (iv) Whereas all pre-treatment isolates of Staphylococcus epidermidis from the anterior nares were susceptible to clindamycin, 6 of 9 post-treatment isolates were resistant, most probably due to selection of resistant organisms.
对41例患有各种感染的患者使用了胃肠外途径给药的克林霉素进行评估。四项主要研究结果如下：（i）静脉注射600毫克克林霉素5小时后，“中度至重度”肝功能不全患者的平均血清浓度为24.3微克/毫升，肝功能正常患者的平均血清浓度为8.3微克/毫升（P<0.02）。这表明，肝病患者可能需要调整克林霉素的剂量。（ii）5小时血清克林霉素水平与血清谷草转氨酶升高程度之间呈正相关。（iii）未观察到明显的副作用。在24例原有肝功能不全的患者中，5例肝功能在治疗期间恶化，5例肝功能改善。（iv）虽然所有治疗前从鼻前庭分离出的表皮葡萄球菌菌株对克林霉素敏感，但治疗后9株菌株中有6株耐药，这很可能是由于耐药菌的选择所致。
