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The aqueous extract of Rhodiola sachalinensis root enhances the expression of inducible nitric oxide synthase gene in RAW264.7 macrophages.

作者信息

Seo W G, Pae H O, Oh G S, Kim N Y, Kwon T O, Shin M K, Chai K Y, Chung H T

机构信息

Department of Microbiology and Immunology, Wonkwang University School of Medicine, 570-749, Chonbuk, South Korea.

出版信息

J Ethnopharmacol. 2001 Jun;76(1):119-23. doi: 10.1016/s0378-8741(01)00220-3.

DOI:10.1016/s0378-8741(01)00220-3
PMID:11378293
Abstract

In the present study, we examined the effects of the aqueous extract of Rhodiola sachalinensis root (RSE) on the expression of inducible nitric oxide (NO) synthase (iNOS) gene in RAW264.7 macrophages. RSE synergistically increased NO synthesis in interferon-gamma-primed macrophages. Reverse transcriptase polymerase chain reaction and Northern blotting analysis revealed that RSE may provide a second triggering signal for the synergistic induction of iNOS mRNA expression. Thus, iNOS-mediated NO synthesis in response to RSE may be one mechanism whereby this herbal medicine elicits its therapeutic effects.

摘要

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