古巴抗脑膜炎球菌BC疫苗诱导的免疫反应及可能参与其提供保护作用的新效应机制。
Immune response induction and new effector mechanisms possibly involved in protection conferred by the Cuban anti-meningococcal BC vaccine.
作者信息
Pérez O, Lastre M, Lapinet J, Bracho G, Díaz M, Zayas C, Taboada C, Sierra G
机构信息
Department of Basic and Clinical Immunology, Finlay Institute, Havana City, Cuba.
出版信息
Infect Immun. 2001 Jul;69(7):4502-8. doi: 10.1128/IAI.69.7.4502-4508.2001.
Abstract
This report explores the participation of some afferent mechanisms in the immune response induced by the Cuban anti-meningococcal vaccine VA-MENGOC-BC. The induction of delayed-type hypersensitivity in nursing babies and lymphocyte proliferation after immunization is demonstrated. The presence of gamma interferon IFN-gamma and interleukin-2 (IL-2) mRNAs but absence of IL-4, IL-5, and IL-10 mRNAs were observed in peripheral blood mononuclear cells from immunized subjects after in vitro challenge with outer membrane vesicles. In addition, some effector functions were also explored. The presence of opsonic activity was demonstrated in sera from vaccinees. The role of neutrophils as essential effector cells was shown. In conclusion, we have shown that, at least in the Cuban adult population, VA-MENGOC-BC induces mechanisms with a T-helper 1 pattern in the afferent and effector branches of the immune response.
摘要
本报告探讨了一些传入机制在古巴抗脑膜炎球菌疫苗VA - MENGOC - BC诱导的免疫反应中的参与情况。证实了在哺乳婴儿中诱导迟发型超敏反应以及免疫后淋巴细胞增殖。在用外膜囊泡进行体外刺激后，在免疫受试者的外周血单核细胞中观察到γ干扰素IFN - γ和白细胞介素 - 2（IL - 2）mRNA的存在，但未观察到IL - 4、IL - 5和IL - 10 mRNA的存在。此外，还探讨了一些效应功能。在疫苗接种者的血清中证实了调理活性的存在。显示了中性粒细胞作为重要效应细胞的作用。总之，我们已经表明，至少在古巴成年人群中，VA - MENGOC - BC在免疫反应的传入和效应分支中诱导具有辅助性T细胞1型模式的机制。
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