Vafai A, Berger M
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Am J Med Sci. 2001 Jun;321(6):372-80. doi: 10.1097/00000441-200106000-00003.
Varicella-zoster virus (VZV), a member of the human herpesvirus family, causes childhood chickenpox (varicella), becomes latent in sensory ganglia, and reactivates years later in immunocompromised and elderly persons to produce shingles (herpes zoster). Early in the AIDS epidemic, zoster was noted in adults and children infected with HIV. Severe and debilitating zoster-associated dermatological, ophthalmic, and neurological complications may occur in patients infected with HIV. Antiviral therapy can modify the duration of zoster and alleviate its attendant complications. Varicella vaccine may boost the immunity and prevent virus reactivation. VZV immune globulin (VZIG) prevents or modifies clinical illness in persons who have been exposed to varicella or zoster.
水痘带状疱疹病毒（VZV）是人类疱疹病毒家族的成员，可引起儿童水痘，潜伏于感觉神经节，并在多年后于免疫功能低下者和老年人中重新激活，引发带状疱疹。在艾滋病流行早期，就已在感染HIV的成人和儿童中发现带状疱疹。感染HIV的患者可能会出现严重且使人衰弱的带状疱疹相关皮肤、眼科和神经并发症。抗病毒治疗可以缩短带状疱疹病程并减轻其伴随的并发症。水痘疫苗可以增强免疫力并预防病毒重新激活。水痘带状疱疹免疫球蛋白（VZIG）可预防或减轻接触过水痘或带状疱疹者的临床病症。
