D'Incalci M, Facchinetti T, Bolis G, Mangioni C, Morasca L
Eur J Drug Metab Pharmacokinet. 1979;4(2):83-5. doi: 10.1007/BF03189405.
We have studied Cyclophosphamide (Cy) pharmacokinetics in 9 patients after their first intravenous dose of 100 mg, and in 9 patients after 6--13 months of continual treatment with the same dose every day. The half-life of Cy was shorter (p less than 0.05) in the latter group, the Co was greater (less than 0.01) and the Vd was clearly less (p less than 0.01). The AUC was unchanged.
我们研究了9例患者首次静脉注射100毫克环磷酰胺（Cy）后的药代动力学，以及9例患者每天使用相同剂量持续治疗6至13个月后的药代动力学。Cy的半衰期在后一组中较短（p<0.05），血药浓度-时间曲线下面积（Co）较高（<0.01），而分布容积（Vd）明显较小（p<0.01）。曲线下面积（AUC）未发生变化。
