Branthwaite M A
Thorax. 1975 Jun;30(3):258-61. doi: 10.1136/thx.30.3.258.
A previous study of neurological damage related to open-heart surgery suggested that the onset of cardiopulmonary bypass is a time of particular hazard, and there is evidence that both microemboli from the extracorporeal circulation and inadequate cerebral perfusion may be contributory factors. Measures to eliminate or minimize these hazards have been introduced, and a clinical survey has been undertaken to evaluate their efficacy. There has been a very highly significant decrease in the incidence of neurological damage as judged by comparison with the results of a similar survey carried out before these measures were introduced. In spite of limitations imposed by differences in workload, perfusion techniques, and methods of data collection, it is concluded that the prophylactic measures have been responsible for the reduction in the incidence of neurological damage.
先前一项关于心脏直视手术相关神经损伤的研究表明，体外循环开始阶段是一个特别危险的时期，有证据表明来自体外循环的微栓子和脑灌注不足都可能是促成因素。已经采取措施消除或尽量减少这些危害，并进行了一项临床调查以评估其效果。与在采取这些措施之前进行的类似调查结果相比，神经损伤的发生率有非常显著的下降。尽管存在工作量、灌注技术和数据收集方法差异带来的局限性，但得出的结论是，预防性措施导致了神经损伤发生率的降低。
