Larsen L E, Tegtmeier C, Pedersen E
Danish Veterinary Laboratory, Copenhagen, Denmark.
Acta Vet Scand. 2001;42(1):113-21. doi: 10.1186/1751-0147-42-113.
The present report describes the clinical, pathological, serological and virological findings in calves from 2 larger Danish beef herds experiencing outbreaks of pneumonia. The calves had been vaccinated with an inactivated bovine respiratory syncytial virus (BRSV) vaccine 2 months prior to the outbreak. The clinical signs comprised nasal discharge, pyrexia, cough and increased respiratory rates. A total of 28 calves died in the 2 herds. The laboratory investigations revealed that BRSV was involved and probably initiated both outbreaks. Furthermore, the serological results suggested that the vaccine induced only sparse levels of antibodies probably due to the presence of maternally derived antibodies at the time of vaccination. Necropsy findings in 5 calves revealed changes typical for infectious pneumonia with involvement of BRSV. In conclusion, vaccination of calves against BRSV in 2 Danish beef herds failed to protect the calves against severe or even fatal BRSV mediated respiratory disease 2 months later.
本报告描述了丹麦两个较大的肉牛群中犊牛发生肺炎疫情时的临床、病理、血清学和病毒学调查结果。在疫情爆发前两个月，这些犊牛已接种了灭活牛呼吸道合胞病毒（BRSV）疫苗。临床症状包括鼻液、发热、咳嗽和呼吸频率增加。两个牛群中共有28头犊牛死亡。实验室调查显示，BRSV与疫情有关，可能引发了这两起疫情。此外，血清学结果表明，疫苗诱导产生的抗体水平很低，可能是由于接种疫苗时存在母源抗体。对5头犊牛的尸检结果显示出BRSV感染性肺炎的典型病变。总之，丹麦两个肉牛群中的犊牛接种BRSV疫苗未能在两个月后保护犊牛免受严重甚至致命的BRSV介导的呼吸道疾病的侵害。
