Kuo T, Shih L Y
Department of Pathology, Chang Gung University School of Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Int J Surg Pathol. 2001 Jan;9(1):29-35. doi: 10.1177/106689690100900106.
The histologic type of thymomas associated with pure red cell aplasia (PRCA) has generally been regarded to be predominantly the spindle cell type. The 5 thymomas associated with PRCA we studied showed various histologic types and none of them was a spindle cell thymoma. Some cases reported as spindle cell thymoma associated with PRCA in the literature might not be spindle cell type. The discrepancy could be due to the lack of consensus in the histologic classification of thymomas in the past. Our study showed that thymomas associated with PRCA lacked a strong correlation with a particular histologic type and the pathogenesis of PRCA associated with thymoma did not seem to be related to the histologic type. One of our cases was an unusual composite tumor of an organoid thymoma (WHO type B1) and a hitherto undescribed "lipofibroadenoma." The clinical outcome was influenced by the invasive character and the histologic type of the thymoma.
与纯红细胞再生障碍性贫血（PRCA）相关的胸腺瘤组织学类型通常被认为主要是梭形细胞型。我们研究的5例与PRCA相关的胸腺瘤呈现出多种组织学类型，且均非梭形细胞胸腺瘤。文献中一些报道为与PRCA相关的梭形细胞胸腺瘤病例可能并非梭形细胞类型。这种差异可能是由于过去胸腺瘤组织学分类缺乏共识所致。我们的研究表明，与PRCA相关的胸腺瘤与特定组织学类型缺乏强相关性，且与胸腺瘤相关的PRCA发病机制似乎与组织学类型无关。我们的其中一例是类器官胸腺瘤（世界卫生组织B1型）与一种迄今未描述的“脂肪纤维腺瘤”组成的罕见复合肿瘤。临床结局受胸腺瘤的侵袭性特征和组织学类型影响。
