宫颈肿瘤患者宫颈阴道冲洗液中的细胞因子
Cytokines in cervicovaginal washing fluid from patients with cervical neoplasia.
作者信息
Tjiong M Y, van der Vange N, ter Schegget J S, Burger M P, ten Kate F W, Out T A
机构信息
Department of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, The Netherlands.
出版信息
Cytokine. 2001 Jun 21;14(6):357-60. doi: 10.1006/cyto.2001.0909.
Human papillomavirus (HPV) infections play an important role in the development of cervical neoplasia. To get to a better understanding of the role of cytokines in the development of these neoplasias, we analysed the presence of various cytokines in cervicovaginal washings of healthy volunteers (n=22), cervical intraepithelial neoplasia (CIN) patients (n=63) and cervical cancer patients (n=33). IL-12p40, IL-10, TGF-beta1, TNF-alpha and IL-1beta levels were significantly higher in patients with cervical cancer than in controls and CIN patients. The levels of IFN-gamma were not different. Our data demonstrate alterations in the local cervical immune environment in cervical cancer patients. This could have important consequences for the further development of immune modulating therapies and vaccination strategies.
人乳头瘤病毒（HPV）感染在宫颈肿瘤的发生发展中起重要作用。为了更好地理解细胞因子在这些肿瘤发生发展中的作用，我们分析了健康志愿者（n = 22）、宫颈上皮内瘤变（CIN）患者（n = 63）和宫颈癌患者（n = 33）宫颈阴道灌洗液中多种细胞因子的存在情况。宫颈癌患者中白细胞介素-12p40（IL-12p40）、白细胞介素-10（IL-10）、转化生长因子-β1（TGF-β1）、肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）水平显著高于对照组和CIN患者。干扰素-γ（IFN-γ）水平无差异。我们的数据表明宫颈癌患者局部宫颈免疫环境发生了改变。这可能对免疫调节治疗和疫苗接种策略的进一步发展产生重要影响。
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