Kourilsky P, Truffa-Bachi P
Department of Immunology, Institut Pasteur, 75724 Paris, Cedex 15, France.
Trends Immunol. 2001 Sep;22(9):502-9. doi: 10.1016/s1471-4906(01)02012-9.
Certain cells that participate in the immune response are known to become polarized in their production of cytokines. It is postulated that, after initial polarization at the site of antigenic encounter, the different types of cell arriving at this site are induced to conform to the local cytokine field, implying that they share common regulatory circuits. As they migrate, these cells might, in turn, spread the particular cytokine field. Therefore, the field is 'infectious' in nature. Propagation of the cytokine field must be regulated somehow. The invasion of the cytokine field into an organ or the entire body could have major immunological consequences.
已知某些参与免疫反应的细胞在细胞因子产生方面会发生极化。据推测，在抗原接触部位初始极化后，到达该部位的不同类型细胞会被诱导顺应局部细胞因子环境，这意味着它们共享共同的调节回路。当这些细胞迁移时，它们可能反过来传播特定的细胞因子环境。因此，这种环境本质上是“传染性的”。细胞因子环境的传播必须以某种方式受到调节。细胞因子环境侵入器官或整个身体可能会产生重大的免疫学后果。
