Meineke F A, Potten C S, Loeffler M
Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany.
Cell Prolif. 2001 Aug;34(4):253-66. doi: 10.1046/j.0960-7722.2001.00216.x.
We present a novel class of spatial models of cell movement and arrangement applied to the two-dimensional cellular organization of the intestinal crypt. The model differs from earlier approaches in using a dynamic movement on a lattice-free cylindrical surface. Cell movement is a consequence of mitotic activity. Cells interact by viscoelastic forces. Voronoi tessellation permits simulations of individual cell boundaries. Simulations can be compared with experimental data obtained from cell scoring in sections. Simulation studies show that the model is consistent with the experimental results for the spatial distribution of labelling indices, mitotic indices and other observed phenomena using a fixed number of stem cells and a fixed number of transit cell divisions.
我们提出了一类新型的细胞运动和排列空间模型，应用于肠道隐窝的二维细胞组织。该模型与早期方法的不同之处在于，它在无晶格的圆柱表面上进行动态运动。细胞运动是有丝分裂活动的结果。细胞通过粘弹性力相互作用。Voronoi镶嵌允许对单个细胞边界进行模拟。模拟结果可以与从切片中的细胞评分获得的实验数据进行比较。模拟研究表明，该模型在使用固定数量的干细胞和固定数量的过渡细胞分裂时，对于标记指数、有丝分裂指数和其他观察到的现象的空间分布，与实验结果一致。
