Mayer A S, Newman L S
Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.
Respir Physiol. 2001 Oct;128(1):3-11. doi: 10.1016/s0034-5687(01)00258-4.
Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality throughout a large part of the western world. Although personal tobacco use has been implicated in a large number of these cases, it is also true that only a fraction of smokers ever develop respiratory problems. Therefore, the question of host susceptibility and other environmental factors should be considered. This paper will briefly review evidence for host susceptibility to COPD, review evidence for additional environmental risk factors for the development of COPD, and give an example of environmental interactions with a known genetic risk factor that further increase the risk of COPD.
慢性阻塞性肺疾病（COPD）是西方世界大部分地区发病和死亡的主要原因。虽然个人吸烟与大量此类病例有关，但确实只有一小部分吸烟者会出现呼吸道问题。因此，应考虑宿主易感性和其他环境因素的问题。本文将简要回顾宿主对COPD易感性的证据，回顾COPD发生的其他环境风险因素的证据，并举例说明环境与已知遗传风险因素的相互作用如何进一步增加COPD的风险。
