Kraft M, Simmen D, Casas R, Pfaltz M
Department of Otorhinolaryngology, Kantonsspital Liestal, Rheinstrasse 41, CH-4420 Liestal, Switzerland.
J Laryngol Otol. 2001 Sep;115(9):709-14. doi: 10.1258/0022215011908955.
Recent investigations have suggested human papillomavirus (HPV) to be involved in the development of sinonasal papillomas (SNP). Forty-three patients operated for SNP were studied to determine the prevalence of HPV-DNA sequences in these tumours and to evaluate their value as a prognostic parameter. The original sections of all cases were reviewed and reclassified according to the WHO. Paraffin blocks available from 37 patients were subjected to in situ hybridization (ISH) and polymerase chain reaction (PCR). Histology revealed 34 cases of inverted papilloma (IP) (79 per cent), five cases of exophytic papilloma (EP) (12 per cent) and four cases of columnar cell papilloma (CCP) (nine per cent). Recurrences developed in seven of 41 patients (17 per cent), and malignancy occurred in four of 43 patients (nine per cent). HPV was detected in four of 37 specimens (11 per cent) both by ISH and PCR. In particular, HPV-11 was found in three lesions (two EP, one IP) (eight per cent), and HPV-6b was detected in one lesion (one EP) (three per cent). Our findings suggest a possible role for HPV in the pathogenesis of exophytic papillomas. As no correlation was found to malignancy and recurrence of disease, screening for HPV seems not to be useful as a prognostic parameter.
近期研究表明，人乳头瘤病毒（HPV）与鼻窦乳头状瘤（SNP）的发生有关。对43例接受SNP手术的患者进行了研究，以确定这些肿瘤中HPV-DNA序列的患病率，并评估其作为预后参数的价值。根据WHO对所有病例的原始切片进行复查和重新分类。对37例患者的石蜡块进行原位杂交（ISH）和聚合酶链反应（PCR）。组织学检查显示34例内翻性乳头状瘤（IP）（79%）、5例外生性乳头状瘤（EP）（12%）和4例柱状细胞乳头状瘤（CCP）（9%）。41例患者中有7例（17%）复发，43例患者中有4例（9%）发生恶变。通过ISH和PCR在37份标本中的4份（11%）检测到HPV。具体而言，在3个病变（2例EP，1例IP）（8%）中发现HPV-11，在1个病变（1例EP）（3%）中检测到HPV-6b。我们的研究结果表明HPV在外生性乳头状瘤的发病机制中可能起作用。由于未发现与疾病恶变和复发相关，因此HPV筛查似乎不能作为一个有用的预后参数。
