西尼罗河病毒与库京病毒之间的关系。
The relationships between West Nile and Kunjin viruses.
作者信息
Scherret J H, Poidinger M, Mackenzie J S, Broom A K, Deubel V, Lipkin W I, Briese T, Gould E A, Hall R A
机构信息
Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia.
出版信息
Emerg Infect Dis. 2001 Jul-Aug;7(4):697-705. doi: 10.3201/eid0704.010418.
Until recently, West Nile (WN) and Kunjin (KUN) viruses were classified as distinct types in the Flavivirus genus. However, genetic and antigenic studies on isolates of these two viruses indicate that the relationship between them is more complex. To better define this relationship, we performed sequence analyses on 32 isolates of KUN virus and 28 isolates of WN virus from different geographic areas, including a WN isolate from the recent outbreak in New York. Sequence comparisons showed that the KUN virus isolates from Australia were tightly grouped but that the WN virus isolates exhibited substantial divergence and could be differentiated into four distinct groups. KUN virus isolates from Australia were antigenically homologous and distinct from the WN isolates and a Malaysian KUN virus. Our results suggest that KUN and WN viruses comprise a group of closely related viruses that can be differentiated into subgroups on the basis of genetic and antigenic analyses.
直到最近，西尼罗河（WN）病毒和库京（KUN）病毒还被归类为黄病毒属中的不同类型。然而，对这两种病毒分离株的基因和抗原研究表明，它们之间的关系更为复杂。为了更好地界定这种关系，我们对来自不同地理区域的32株库京病毒分离株和28株西尼罗河病毒分离株进行了序列分析，其中包括一株来自纽约近期疫情的西尼罗河病毒分离株。序列比较显示，来自澳大利亚的库京病毒分离株紧密聚集在一起，但西尼罗河病毒分离株表现出很大差异，可分为四个不同的组。来自澳大利亚的库京病毒分离株在抗原上是同源的，与西尼罗河病毒分离株以及一株马来西亚库京病毒不同。我们的结果表明，库京病毒和西尼罗河病毒构成了一组密切相关的病毒，可根据基因和抗原分析将它们分为不同的亚组。
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