高压氧作为毛霉病的辅助治疗：小鼠模型中的随机对照试验
Hyperbaric oxygen as an adjunct in zygomycosis: randomized controlled trial in a murine model.
作者信息
Barratt D M, Van Meter K, Asmar P, Nolan T, Trahan C, Garcia-Covarrubias L, Metzinger S E
机构信息
Section of Emergency Medicine and Hyperbaric Medicine, Department of Medicine, Louisiana State University, New Orleans, Louisiana 70112, USA.
出版信息
Antimicrob Agents Chemother. 2001 Dec;45(12):3601-2. doi: 10.1128/AAC.45.12.3601-3602.2001.
Abstract
Zygomycosis was induced by injecting CD-1 mice with 5 mg of intraperitoneal deferoxamine and then 10(6) CFU of intravenous and intrasinus Rhizopus arrhizus. The addition of hyperbaric oxygen (2.0 atm absolute twice daily) to amphotericin B did not improve survival over that achieved with amphotericin B and placebo air treatments.
摘要
通过给CD-1小鼠腹腔注射5毫克去铁胺，然后静脉注射和鼻窦内注射10(6)CFU的少根根霉来诱发接合菌病。与两性霉素B和安慰剂空气治疗相比，在两性霉素B治疗基础上加用高压氧（绝对压力2.0个大气压，每日两次）并不能提高生存率。
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